ischemic cascade

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ischemic cascade

Vascular disease A series of events lasting for hrs to several days after an initial ischemic event that results in extensive necrosis and tissue damage beyond the tissue zone first affected by the initial lack of blood flow

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As a thrombosis or emboli cause a decrease in blood supply to the brain tissue, events occur at the cellular level, referred to as the ischemic cascade. Neurons and support cells require a careful balance of variables such as temperature, pH, nutrition, and waste removal in their environment to function optimally (Hinkle & Bowman, 2003).

Acute ischemic stroke review

A lack of blood supply to the ischemic area of the brain known as the penumbra initiates an ischemic cascade whereby brain function stops if oxygen deprivation exceeds 60 to 90 seconds and brain tissue dies within 3 hours of anoxia leading to cerebral infarction.

A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke

Decreased blood flow to the brain deprives the brain of oxygen, triggering the ischemic cascade that includes calcium influx, overstimulation of excitatory amino acids, and overproduction of free radicals.

Predictive value of biochemical markers in stroke

We believe the model of postmortem CSF may partly reproduce mechanisms underlying the ischemic cascade of events leading to stroke lesions and, as such, may confer scientific plausibility to the biomarkers identified.

PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke

Fig 1 provides an overview of these alterations, referred to as the ischemic cascade. Improved understanding of this pathophysiology has led basic science researchers to investigate new treatments for ischemic injury.

Neuroprotection for ischemic stroke. (Pharmacology Update)

The exact level at which lubeluzole acts in the ischemic cascade remains to be determined.[33]

Neuroprotective and thrombolytic agents: advances in stroke treatment

This ischemic cascade continues as pronounced cellular and neurological dysfunction ensue and excitatory neurotransmitters, such as glutamate and aspartate are released into the extracellular space.

Overview: hyperacute rt-PA stroke treatment

The ischemic cascade is a complex process that occurs at the cellular level.

Pathophysiology and mechanisms of acute ischemic stroke

Ischemic stroke is considered to be caused by decreased blood flow to brain tissue, followed by the activation of the ischemic cascade which leads to cell death and severe neuronal damage [26], which includes apoptosis, oxidative stress, inflammation, and calcium overload.

Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats

Myocardial ischemia involves a typical sequence of events termed the "ischemic cascade," shown in Figure 2.

Cardiac MRI: A preferred method for assessing myocardial ischemia and infarct burden

The lack of oxygen results in energy deprivation and the ischemic cascade starts with an arterial thromboembolic episode.

Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research

Inflammation is a crucial contributor in the ischemic cascade after cerebral ischemia that results in harmfully augmenting "secondary injury".

LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats