ischemic cascade


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ischemic cascade

Vascular disease A series of events lasting for hrs to several days after an initial ischemic event that results in extensive necrosis and tissue damage beyond the tissue zone first affected by the initial lack of blood flow
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Management of acute Stroke: Techniques that are used to minimize the injury to the brain in the event of an ischemic insult can be thought of as having three broad purposes: to increase the supply of oxygen to the injured tissue, to reduce the metabolic demands, or to affect specific pathways in the ischemic cascade to reduce the production of unwanted metabolites.
The multifactorial nature of cell injury is an alternate formulation of the same information used to construct the ischemic cascade.
Known as an ischemic cascade, this drop-off of oxygen results in a sudden crush of metabolic waste that damages cell membranes as well as the mitochondria, a part of the cell that generates chemical energy and is involved in cell growth and death.
Ischemic stroke initiates a generalized series of events occurring at the onset of cerebral ischemia, referred to as the ischemic cascade (Fig.
Intensive basic scientific research during the last two decades has given healthcare professionals an increased understanding of the ischemic cascade in the format of the precise environmental alterations involved in the pathophysiology of ischemic injury at the cellular level.
The impact of systemic blood pressure and subsidiary maintenance of cerebral perfusion pressure are basic elements of stroke pathophysiology, yet colossal research efforts have been diverted toward the more elusive goal of identifying critical molecular targets in the ischemic cascade.
Neuroprotective drugs, which boast the ability to halt the ischemic cascade, offer huge hope to sufferers, but as yet, no such compound has received US approval.
Decreased blood flow to the brain deprives the brain of oxygen, triggering the ischemic cascade that includes calcium influx, overstimulation of excitatory amino acids, and overproduction of free radicals.
Prolonged ischemia results in a stereotypical series of biochemical events leading to eventual cell death, the so-called ischemic cascade.
Fox stated: "Because of its action on fundamental cellular function, CPC-111 is the only compound that is known to act on multiple processes which contribute to the toxic ischemic cascade.
Fig 1 provides an overview of these alterations, referred to as the ischemic cascade.
The exact level at which lubeluzole acts in the ischemic cascade remains to be determined.