irritate

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irritate

(ĭr′ĭ-tāt′)
v. irri·tated, irri·tating, irri·tates
v.tr.
1. To cause (someone) to feel impatient or angry; annoy: a loud, bossy voice that irritates listeners.
2. To make sore or inflamed: The smoke irritated my eyes.
3. Physiology To cause a physiological response to a stimulus in (a cell, body tissue, or organism).
v.intr.
To be a cause of impatience or anger.

ir′ri·tat′ing·ly adv.
ir′ri·ta′tor n.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in classic literature ?
"Irritate him?" said the lady; "sure, you are as great a fool as himself.
Because I admired these barbarities of Poe's, I wished to irritate them, to spit some hapless victim on my own spear, to make him suffer and to make the reader laugh.
'Their bellies expand too quickly, which irritates the diaphragm,'.
Any assault on my integrity irritates me, to say the least.'
I will leave you with this thought, and probably live to regret it, what irritates you about me?
It irritates me that the NBC and others speak of the freedom fighters of Syria as rebels.
The thought of it actually makes me feel sick and he irritates me.