TABLE 2 Typical Laboratory Values in Normal Subjects and Patients with Hereditary Hemochromatosis Test Normal Test Range HHC Patients Serum iron ([micro] g/dL) 38-180 180-300 Serum unsaturated iron-binding capacity
>50% <50% Serum transferrin (([micro] g/dL) 220-410 200-300 Transferrin saturation 16%-50% 55%-100% [(serum iron [[micro] g/dL] divided by TIBC [[micro] g/dL])] x 100 Transferrin index 0.
Although iron and cholesterol assays are deemed moderately complex, iron-binding capacity
and HDL cholesterol tests are complex because they require a pretreatment step.
The relation between chemically measured total iron-binding capacity
concentrations and immunologically measured transferrin concentrations in human serum.
high saturation of serum iron-binding capacity
and high iron levels.
There is one code for the iron and another one for the iron-binding capacity
Iron-deficiency anemia should be suspected if the patient has a low serum ferritin, high total iron-binding capacity
, low serum iron, and low transferrin saturation.
Additional assays for aldolase, al-antitrypsin, amylase, angiotensin-converting enzyme (ACE), bile acids, direct bilirubin, ceruloplasmin, complement C4, complement C3, high-sensitivity C-reactive protein, creatine kinase, fructosamine, HDL-cholesterol, haptoglobin, iron, lipoprotein(a), lipase, LDL-cholesterol, magnesium, prealbumin, pancreatic amylase, phospholipids, transferrin, triglycerides, total iron-binding capacity
, and unbound iron-binding capacity
were performed only on the Roche Modular P analyzer.
Low serum iron and ferritin, and high total iron-binding capacity
TIBC: The sum of the serum iron plus the unsaturated iron-binding capacity
For those elderly patients with anemia and normal red blood cell indices, the questionnaire asked which further test would be ordered (options included blood smear, reticulocyte count, stool for blood, serum iron levels, iron-binding capacity
, serum ferritin levels, serum vitamin B[.
A test for iron, total iron-binding capacity
, percentage saturation of iron-binding capacity
, ferritin and soluble transferrin receptor levels will distinguish anemia of chronic disease (ACD) from iron-deficiency anemia (IDA).