Keywords: Hepcidin, Anaemia, Iron metabolism
, Iron, Inflammation.
Inhibition of oxygen-sensing prolyl hydroxylase enzymes stabilises hypoxia-inducible factors, which can lead to transcription of erythropoietin and other genes involved in the production of red blood cells and iron metabolism
, similar to the physiological effects that occur in the body at high altitude.
JTZ-951 is an enarodustat which is expected to be used to accelerate production of endogenous erythropoietin, controlling the expression of molecules responsible for iron metabolism
and promoting the production of red blood cells.
A Red Carpet for Iron Metabolism
Cell 2017; 168(3): 344-61.
Researchers first noticed this connection in people with iron metabolism
disorders such as sickle cell disease.
During anemia, hepcidin creates an important link between the body's defense, inflammation, and iron metabolism
. A previous study has shown that during infection and inflammation, hepcidin synthesis is considerablely increased owing to stimulation by IL-6.5 Chemerin is a recently discovered antimicrobial protein and adipokine.
has a critical importance for normal cognitive and motor development in children and furthermore it is essential for immune system [11, 12].
Lactoferrin Supplements Market: Dynamics Growing health consciousness among consumers is a major factor driving the growth of the lactoferrin supplement market as lactoferrin regulates iron metabolism
, acts as an antibacterial agent, has antioxidant properties and thus, helps in improving immunity.
While monocyte-derived macrophage plays a central role in iron metabolism
in addition to phagocytosis and immune response, in the case of iron dysregulation, macrophage function can be attenuated (10).
In animals, including humans, many of the iron-containing cofactors that are essential are synthesized in a cellular organelle called the mitochondrion, which consequently has a high requirement for iron and can be regarded as the major cellular hub for iron metabolism
. Despite its importance, we currently have a rather incomplete picture of how iron is regulated in mitochondria.
Patients who had diseases that disrupted iron metabolism
or were tobacco users, and those on antidepressants, anxiolytics, or antipsychotics were excluded from the study.
Hepatocytes control iron metabolism
by producing haptoglobin.