irisin

ir·i·din

(ir'i-din),
1. Irigenin 7-glucoside from orris root, Iris florentina.
2. A resinoid from blue flag, Iris versicolor; used as a cholagogue and cathartic. Synonym(s): irisin

irisin

(ī′rĭs-ĭn) [Gr. Iris, rainbow, and the Gr goddess who was messenger of the Olympian gods + -in]
A hormone released by active muscle cells that converts metabolically inactive white fat to brown fat.
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References in periodicals archive ?
2], in a study to assess whether a molecular link exists between circulating irisin levels and the length of telomeres--the end caps of chromosomes which are thought to be a marker of aging.
Working with Birmingham volunteers, researchers discovered a potential link between Irisin, a recently identified hormone released from muscle after exercising, and the healthy ageing process.
Researchers have found that the hormone, known as Irisin, can "predict" how quickly someone is ageing.
We identified two hormones that are stimulated by cold - irisin and FGF21 - released from shivering muscle and brown fat respectively," said study leader Dr Paul Lee, of Sydney University.
The protein, called FNDC5, is produced by the exertion of our muscles and is then released into the bloodstream as a hormone called irisin.
Irisin is regulated by PGC1A, secreted from muscle to plasma after exercise and promotes the formation of brown fat via an unknown receptor.
Previously, assays for novel biomarkers such as caveolin-1, irisin, meprin A, and filimin B have not been commercially available; however, kits for the measurement of hundreds of such analytes in humans, dog, horse, mouse, rat, cow, monkey, pig, and a variety of other species can now be purchased from distributors in the US, Europe, and other parts of the world.
In the new report, Spiegelman's team, led by first author, Jun Wu, PhD, also found that beige cells are specifically targeted by the hormone irisin, which muscle cells express during exercise.
It's irisin that some have christened "exercise in a pill.
Researchers publishing online in January delivered the news that PGC1-alpha expression in muscle stimulates an increase in irisin.
Previously, Ember announced the licensing of technology to several biologics including irisin and BMP7, and has secured licensing to several functional/pathway screens that are key to its brown fat pipeline, including PRDM16 and Foxc2.