studied the KRAS mutation status of 113 patients with irinotecan
refractory mCRC treated with cetuximab in clinical trials .
The recommendation was for use in combination with chemotherapy and alone in patients who have failed oxaliplatin- and irinotecan-based therapy and who are intolerant to irinotecan
The dose of irinotecan
in the EPIC trial was 350 mg/[m.sup.2] per week for 3 weeks.
SN-38, the active metabolite of irinotecan
, is widely used by many new drug companies to develop new camptothecin derivatives.
into a liposome developed by Terumo, the new agent will be able to sustain its effectiveness and improve its concentration in cancer tissues while reducing side effects.
We previously suggested that determination of the UGT1A1 polymorphisms before irinotecan
treatment could be clinically useful and important for predicting and preventing related toxicities (1).
In 1994 AIDS Treatment News reported on a class of drugs being developed for cancer, but not for HIV, though some experts believed they should be tested as antiretrovirals (see Topotecan, CPT-11 (Irinotecan
), Camptothecin, and Other Topoisomerase I Inhibitors, AIDS Treatment News #197, April 15, 1994).
Led by Hidehiko Saito, the team examined the base sequences in blood samples taken from 108 cancer patients, including people suffering from lung cancer, who had been administered the anticancer drug irinotecan
ENPNewswire-August 9, 2019--Starpharma commences phase 1/2 DEP irinotecan
M2 PHARMA-July 9, 2019-Ipsen and Servier Release Initial Phase 1/2 Clinical Data Evaluating Liposomal Irinotecan
as an Investigational First-line Treatment for Metastatic Pancreatic Cancer at ESMO 21st World Congress on Gastrointestinal Cancer
The development of the cytotoxic agents irinotecan
, oxaliplatin and capecitabine and of the biological agents bevacizumab, cetuximab and panitumumab has clearly increased the therapeutic options for patients with metastatic CRC.