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Iproniazid, which used to be recommended as treatment against tuberculosis, attracted the attention of researchers due to its positive, stimulating effects upon patients suffering from tuberculosis, effects that were also observed in patients treated with its precursor, izoniazid.
Toxic effect of iproniazid in a patient with angina.
The second antidepressant to be discovered, iproniazid, was hitherto used as an antibiotic for treating patients with tuberculosis when its mood-elevating properties were observed.
The remaining AMA subtypes may be associated with other diseases: Syphilis (M1), pseudolupus (M3), kollagenosis (M5), drug- induced hepatitis, caused for instance by iproniazid (M6), cardiomyopathies (M7) and primary biliary cirrhosis with poor prognosis (M8).
In 1956, two antidepressants, imipramine and iproniazid, were developed (Grob, 1991), and psychopharmacological treatment for people with SMI further reduced the number of people residing in state mental hospitals (Vondracek & Corneal, 1995).
* Monoamine oxidase inhibitors in 1959, from observations that iproniazid, a drug used in tuberculosis sanitariums, improved the mood of tuberculosis patients.
The discovery that some drugs as iproniazid and imipramine exert an antidepressant effect dates back to the 1950s .
(13), (14) Although myristicin's potency is not comparable to that of the more potent MAO inhibitors such as tranykypromine and iproniazid (which is not available in the United States), it seems adequate when compared with its low toxicity.
Serendipity played a role in the discovery of the first antidepressant, iproniazid, a monoamine oxidase inhibitor (MAOI) that was used to treat tuberculosis in the 1940s and 1950s; medical staff in sanitariums noticed that the drug elevated the mood of depressed tuberculosis patients.
Researchers determined iproniazid's antidepressant effects were the result of blocking removal of the amine group by monoamine oxidase (MAO) from dopamine, norepinephrine, and serotonin.
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