For example, in the same study that agrees with our data and showed that PTU could not inhibit the T4-induced cardiac hypertrophy, another antithyroid drug, sodium ipodate , was able to do it even though the serum T3 levels and other thyroid hormone peripheral effects were comparable in the 2 groups.
Solomon, "A study of cardiac effects of thyroid hormones: Evidence for amelioration of the effects of thyroxine by sodium ipodate," Endocrinology, vol.
Younai, "Use of sodium ipodate in management of hyperthyroidism in subacute thyroiditis," Journal of Clinical Endocrinology and Metabolism, vol.
Inhibition of conversion of T4 to T3 occurs with administration of amiodarone and iodinated contrast media such as ipodate
, iopanoic acid, and tyropanoate.
ELEVATED TSH LOW TSH Recovery from nonthyroidal illness Euthyroid sick syndrome Late evening TSH surge Recovery from normal pregnancy Assay variability Adrenal insufficiency Drugs: metoclopramide, Drugs: glucocorticoids, dopamine amiodarone, cholecystographic dye (sodium ipodate
) Meena Khandelwal, MD Associate Professor, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Cooper University Hospital, University of Medicine and Dentistry of New Jersey, Camden, NJ
An endocrinology consultation was obtained for management of thyroid storm, and the patient was started on methimazole, ipodate, and an esmolol drip.
The esmolol drip was discontinued and the patient was started on an oral beta blocker; the ipodate was eventually stopped.
Iopanoic acid and ipodate
, iodinated contrast media previously used for cholecystography, are potent inhibitors of the conversion of thyroxine (T4) to triiodothyronine (T3), the bioactivethyroid hormone.