The Following contrasts were used in the study population: iohexol (nonionic, monomer, and LOCM); sodium meglumine diatrizoate (ionic, HOCM, and monomer); iopamidol (nonionic, monomer, and LOCM); and ioxaglate
(Ionic, LOCM, and dimer).
In another study, Ribeiro et al (21) investigated NO production in rat renal artery smooth muscle cells primary culture (rVSMC) exposed to contrast medium and found that non ionic iobitridol, low-osmolar ioxaglate
and high-osmolar ioxitalamate caused decreases in NO levels as compared to control.
In vitro, Arranz-Pena and coworkers have compared the interference by 13 different iodinated contrast agents on the Paragon by adding the different agents to control serum, and found that most agents caused a peak in the [alpha]2 fraction, but some agents (sodiummeglumine ioxaglate
, ioversol, and iomeprol) caused interference in the [beta]-fraction (4).
From these data we conclude there is absolutely no indication that iodixanol is less harmful for kidney function than ioxaglate
or iohexol," Dr.
Of interest is the RCM ioxaglate
that whilst it is ionic, it is classified as an LOCM as it is a dimer containing more iodine atoms per particle in solution.
2]-globulin fraction for iohexol, at the anodal site of the [beta]-globulin fraction for sodium-meglumine ioxaglate
, and in the middle of the [beta]-globulin fraction for ioversol.
2], yet hypoperfusion and hypoxia lasted significantly longer following iodixanol than ioxaglate
MacDonald, "A comparative study of the nephrotoxicity of iohexol, iopamidol and ioxaglate
in peripheral angiography," Canadian Association of Radiologists Journal, vol.
However, the risk of CI-AKI with two LOCM including iohexol and ioxaglate
was significantly higher than other LOCM (for example, iopamidol, iopromide, and ioversol) and the IOCM (iodixanol) in many studies [35, 36].
4%) than with either the monomer iopamidol (Niopam 300) or the ionic dimer ioxaglate
administration showed a benefit of iodixanol (n = 1,382) compared to the pooled LOCM population (n = 1, 345) composed of iohexol and ioxaglate
in the vast majority of cases.
De Belder, "A randomized prospective trial of ioxaglate
320 (Hexabrix) vs.