ionotropic


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ionotropic

(ī″ŏn-ŏ-trō′pĭk) [″ + ″]
Having an influence on glutamate-gated cell surface receptors, i.e., on cell membrane channels that open or close in the presence of ions.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies.
The presence of signs of peritonitis and intestinal obstruction along with sepsis associated with low vascular flow states such as sepsis, shock and the need of ionotropic support lead to immediate surgical management of this patient.
Glutamate acts via ionotropic glutamate receptors (iGluR) and metabotropic glutamate receptors (mGluR), both of which have been implicated in AD (52).
The chitosan beads were prepared by the ionotropic gelation method (33) using sodium tripolyphosphate (TPP) as an ionic agent.
An in vivo study reported an increase in the basal glutamate level in aged rats compared with adults.[19] It is impossible to conclude whether fornix DBS reduced the neurotoxicity of enhanced glutamatergic signals or disrupted a memory-related mechanism by glutamate and ionotropic glutamate receptors (e.g., N-methyl-D-aspartate).
NMDA receptors are the member of ionotropic glutamate receptor family and are involved in many brain functions.
The sodium tripolyphosphate (TPP) is a multivalent anion capability of interacting with the amino groups of the CH and forming an ionic network interconnected by means of the ionotropic gelation technique, allowing the attainment of nanoparticles [2].
Other genes including FABP6 (fatty acid binding protein 6), downregulated in the prefrontal cortex in major depression [35]; GRIN1 (glutamate ionotropic receptor NMDA subunit), implicated in stress-related psychiatric disorders [40]; HRH1 (histamine receptor H1), known to be blocked by TCAs [41]; and HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1), associated with female depression [42], were likewise differentially methylated.
AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors (AMPARs and NMDARs, resp.) are crucial in activity-dependent synaptic changes (reviewed in [2-5]).
Two different strategies, physical blending and ionotropic gelation, were adopted to prepare binary or tertiary mixtures and nanoparticulate formulation, respectively.
Other upregulated receptors in competent larvae included seven ionotropic glutamate receptors, two nicotinic acetylcholine-gated receptors, two neurotransmitter-gated ion channels, and a gustatory receptor (Table A6).
Few studies suggest that there is a decrease in the direct chronotropic and ionotropic effect of thyroid hormone on SA node and myocardium by significant reductions in the transcription of pacemaker channels and decrease in vagal activity in hypothyroids compared to control group.