Proline has no
ionizable groups, and all conformations like cisand transare almost isoenergetic.
LogD takes pKa into account and does the same for
ionizable compounds.
The findings establish the role of ApoE as an endogenous targeting ligand for neutrally charged
ionizable LNPs (iLNPs), but not certain cationic LNPs (cLNPs), and demonstrate an alternative targeting strategy for the hepatic delivery of RNAi therapeutics using the carbohydrate N-acetylgalactosamine (GalNAc) as an exogenous ligand.
Data were not collected during the exclusion (5 minutes); thereafter,
ionizable material was recorded as a function of time, and m/z signals were used for eluant identification by comparison with Wiley275 and Nist02 libraries.
This creates unique failure modes, as these are highly
ionizable salts and, as such, are strong electrolytes--materials that conduct electricity in the presence of moisture.
In practice, the mass difference was actually less than 1%, as easily-vaporized and
ionizable uranium tetrachloride was used as the process material.
* To increase the delivery of
ionizable drugs at physiological pH, e.g.
These studies led to the hypothesis that many of the 21 hydroxyl groups on beta-cyclodextrin molecules could be derivatrzed to form a closely related family of analogous chemical compounds containing both polymerizable groups and hydrophilic
ionizable ligand (substrate-binding) groups, each attached via hydrolyticaliy-stablc ether-linkages.