ion channels


Also found in: Dictionary, Encyclopedia.

ion channels

Protein ports in cell membranes that are specific for the passage of sodium, potassium, calcium and chloride ions in solution. Changes in the protein configuration, under the influence of various hormone molecule attachment, intracellular ion or other chemical concentration, or electrical potential, cause ion channels to open or close as required. Many diseases result from disordered function of ion channels.
References in periodicals archive ?
Cell and platforms performance as well as ion channel current expression is thoroughly investigated and summarized in a data sheet.
Early work in the field, done to understand the ion channels whose coordinated opening and closing creates a nerve impulse, was done in exceptionally large cells: the giant nerve cells of the European squid, which had projections big enough to be seen with the unaided eye.
In nerve cells, ion channels work with extreme precision: Sodium channels open for a fraction of a second to allow just enough sodium in to trigger a nerve impulse.
Bett has shown in preliminary data that ion channel expression changes 150-fold during gestation.
Hellmich's research group investigated which structural properties of the ion channel ring are responsible for allowing calcium ions to pass.
Because sour taste is the perception of acidic substances, which have a high concentration of protons, Liman predicted that sour taste cells have an ion channel that responds to or transports protons.
First, we checked the major group, the most frequently investigated ion channels, such as the Na, Ca, transient outward current ([I.sub.to]), delayed rectifier K current ([I.sub.Kr], [I.sub.Ks]), inward rectifier current ([I.sub.K1]), Na/Ca exchanger ([I.sub.NCX]), and funny current (If) channels.
After determining the impacts of potassium ion channels on temporal coherence of network in the presence of autapse, we examine the effects of sodium ion channels known as another important ion channels at determining the firing dynamics of neuron.
Taugher et al., "Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity," Nature Neuroscience, vol.
According to its different targets acting on the organism, the conotoxins can be divided into three categories [3]: (1) acting on voltage-gated ion channels, (2) acting on the ligand-gated ion channel, and (3) acting on other receptors.
Peter Finan, chairman Enterprise Therapeutics, said, "John's experience in ion channels, drug development, and biotech fundraising, position him uniquely to lead Enterprise Therapeutics moving forward.
Leading biomedical researchers based in Qatar, the Mena region, Europe and the Far East met for a conference on 'Ion Channels and Transporters in Health and Disease'.