During the five years in which this study was conducted no instances of urticaria or iodism were observed." (19) "No evidence of iodine-induced allergic phenomena was detected during this study." (17) "Comparative data indicate that disinfection of an Olympic-size swimming pool can be accomplished with iodine at half the dose of chlorination ...
If the dose is properly regulated there need be no fear of iodism or iodine Basedowism."
Thyroid function tests were affected in 4% of the patients and iodism was present in 3% of them.
When the data from Marine's, Klinger's and Ghent's studies (3,10) were evaluated regarding the incidence of iodism in relation to the daily amount of I ingested, a positive correlation was found between those two parameters: 0% iodism at a daily amount of 1.4-2 mg; 0.1% iodism with 3-6 mg daily; 0.5% with 9 mg and 3% with 31-62 mg (Table 2).
From Table 2, we observe that the incidence of iodism increased progressively from 0% at 2 mg to 3% at 31-62 mg.
The equivalent of 0.1 ml of a 5% Lugol solution, that is 12.5 mg I was chosen, a value close to the average intake of 13.8 mg consumed in Japan, (7) a country with a very low incidence of FDB; (5) slightly higher than the 9 mg amount used in Marine's original study (3) of adolescents, with a very low incidence (0.5%) of iodism following this level of I supplementation; also within the range of 10-20 mg used in the Russian study of FDB, without any side effects reported; (8) and five times less than the largest amount of 62 mg used in Ghent's studies with a 3% iodism reported.