iobenguane

iobenguane

 [i″o-ben´gwān]
a norepinephrine analogue that is taken up by the neuroendocrine cells and concentrated in the hormone storage vesicles; labeled with radioactive iodine, it is used for diagnostic imaging of neuroendocrine tumors and disorders of the adrenal medulla.
References in periodicals archive ?
AZEDRA (iobenguane I 131) 555 MBq/mL injection for intravenous use, Ultra-orphan Radiotherapeutic
The company said MRT is an effective form of therapy that uses radiopharmaceuticals including Lutathera (Lu-177 DOTATATE) and Azedra (I-131 iobenguane) to target tumors based on certain receptors that these tumors express.
It also provides an exclusive AdreView planar application for automated heart to mediastinum ratio generation for Iobenguane I-123 images and the Dosimetry Toolkit for a quantitative SPECT and Planar calculation of the Radioisotope Therapy planning value.
(NASDAQ: MIPI), Cambridge, Mass., has initiated a Phase 2a clinical trial of Azedra (Ultratrace(tm) iobenguane I-131 or Ultratrace MIBG) for the treatment of children with high-risk neuroblastoma, a neuroendocrine cancer that primarily affects children.
* There are insufficient data to recommend PET scanning or radionuclide imaging (with iodocholesterol or iobenguane sulfate 1-123) in the evaluation of incidentally detected adrenal masses.
Imaging techniques (iodine 131 iobenguane sulfate I 123) greatly facilitate tumor localization and surgical planning.
AZEDRA (iobenguane I 131) is indicated for the treatment of adult and pediatric patients 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma who require systemic anticancer therapy.
The Azedra (iobenguane I 131) injection for intravenous use has been approved by the US FDA for the treatment of adults and adolescents age 12 and older with rare tumours of the adrenal gland (pheochromocytoma or paraganglioma) that cannot be surgically removed (unresectable), have spread beyond the original tumour site and require systemic anticancer therapy.