involucrin

in·vo·lu·crin

(in'vō-lū'krin), [MIM*147360]
A non-keratin soluble cross-linked protein present on the cytoplasmic aspect of the plasmalemma of a squama.
[fr. L. involucrum, a wrapper]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Steinert, "A novel function for transglutaminase 1: Attachment of long-chain [omega]-hydroxyceramides to involucrin by ester bond formation," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Lipids and the Permeability and Antimicrobial Barriers of the Skin
Putative stem cells residing in the basal limbal epithelium are integrin alpha9 positive and connexin 43, E-cadherin, nestin, involucrin, K12, and K3 negative, with higher expression of EGFR [11].
The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure
For example, the expression of K5 and K14 is restricted to the basal layer, whereas K1 and K10 appear on more differentiated suprabasal cells [4], and involucrin, loricrin, and keratolinin, in the cells of the uppermost spinous layer [1].
HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes
It provides a solid physical barrier and consists of a 10 nm thick layer of highly cross-linked insoluble proteins, such as involucrin, envoplakin, periplakin, loricrin, and small proline-rich protein.
Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis
Loss of function in filaggrin and deficiencies in loricrin, involucrin and claudins lead to epidermal barrier disruption causing transepidermal water loss and xerosis.
Latest updates on atopic dermatitis
Immunohistochemistry was used to observe the expression of loricrin, involucrin, LL37, and human [sz]-defensins 2 (hBD2) in skin lesions.
Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease: Alterations in Skin Barrier Function and Related Molecules
Expression of cornification-related molecules including involucrin, filaggrin, caspase 14 and calcium-sensing receptor was higher in the AH
Biomechanics for the non-specialist AKA "stop being intimidated by biomechanics using one weird tip"
For example, involucrin is a marker whose expression is absent in the parakeratotic areas of ILVEN but present in psoriasis [6].
The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab
On the other hand, in keratinocytes exposed to arsenic expression of involucrin was decreased, a similar pattern being previously highlighted in human cSCC [48].
From normal skin to squamous cell carcinoma: a quest for novel biomarkers
Dvorakova et al., "Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation," Interdisciplinary Toxicology, vol.
Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin
The following polyclonal primary antibodies were obtained from GeneTex (Irvine, USA): rabbit anti-human cytokeratin 5 (CK-5, Cat #GTX113219), cytokeratin 10 (CK-10, Cat #GTX108883), cytokeratin 14 (CK-14, Cat #GTX104124), loricrin (Cat #GTX116013), and involucrin (Cat #GTX116012); rabbit anti-human transglutaminase-1 (TGM-1) polyclonal antibody (Cat #12912-3-AP) was from Proteintech (USA).
Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response
The SC is made up of corneocytes: terminally differentiated keratinocytes, highly cross-linked by transglutaminases with cornified envelope proteins such as loricrin, involucrin, filaggrin, and small proline-rich proteins.
Effects of in utero exposure of C57bl/6J mice to 2,3,7,8-tetrachlorodibenzop-dioxin on epidermal permeability barrier development and function
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