investigational new drug


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in·ves·ti·ga·tion·al new drug

(IND) (in-ves'ti-gā'shŭn-ăl nū drŭg)
A pharmacotherapeutic agent that has not been approved for general use by the U.S. Food and Drug Administration, but is in the course of being tested on humans.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

drug

(drug) [Fr. drogue, chemical material]
Any substance that, when taken into a living organism, may modify one or more of its functions.

drug of abuse

Any agent that impairs behavior, health, social interactions, or thought and lends itself to compulsive use. Many of these agents, including ecstasy, lysergic acid (LSD), methamphetamines, the opiates, and phencyclidine, are considered controlled substances in the U.S. Alcohol and tobacco products are not traditionally considered to be drugs of abuse although they are addictive and harm many people.

antimicrobial drug

A drug that either kills microorganisms or prevents their growth.

antisense drug

Antisense compound.

brake drug

A popular term for a hormonal agent that prevents excessive growth in children.

club drug

A colloquial term for a drug used for its euphoric or intoxicating effects at a party, rave, nightclub, or bar. Such drugs include ecstasy, gamma hydroxybutyrate, ketamine, and rohypnol.

code drug

A drug to treat acute, life-threatening emergencies including dysrhythmias, cardiac arrest, pulmonary edema, and shock. Code drugs include atropine, epinephrine, morphine, and vasopressin.
See: basic life support; code (3); code cart

counterfeit drug

1. Any drug that has been adulterated, contaminated, diluted, or falsely labeled.
2. Any drug marketed under false pretenses.

designer drug

An illicitly produced drug of abuse. Designer drugs include methamphetamine, fentanyl and its analogues, and phencyclidine hydrochloride (PCP). They have serious side effects or are addictive; deaths and injury from overdose are common.

disease-modifying antirheumatic drug

Abbreviation: DMARD
A drug that is used to treat rheumatoid arthritis and acts more slowly but more effectively than nonsteroidal anti-inflammatory drugs. Such drugs include hydroxychloroquine, methotrexate, and tumor necrosis factor inhibitors.
Synonym: slow-acting antirheumatic drug

gateway drug

A drug of abuse whose use precedes, and is thought to contribute to, the subsequent use of more dangerous or exotic substances, esp. by young people.

hard drug

In biochemistry, a drug that is not metabolized by the cytochrome P450 system in the liver, or transported by intestinal P-glycopeptide.

investigational drug

Abbreviation: IND
A drug available only for experimental purposes because its safety and effectiveness have not been proven.
Synonym: investigational new drug

investigational new drug

Investigational drug.

legend drug

A medication that cannot be obtained legally without a prescription from a licensed health care provider.

look-alike drug

1. Any of a group of solid dosage forms of drugs that mimic various prescription drugs by size, shape, color, and markings. Some of these may be controlled drugs.
2. A drug that works much like another but varies in a minor or insignificant part of its chemical structure.

neuromuscular blocking drug

A type of drug used during the administration of anesthesia to allow surgical access to body cavities, esp. in particular the abdomen and thorax, by preventing voluntary or reflex muscle movement. These drugs are also used to facilitate compliance in critically ill patients undergoing intensive therapy such as mechanical ventilation.

new drug

A drug for which premarketing approval is required by the Food, Drug and Cosmetic Act (a U.S. law granting authority to the FDA to oversee the safety of food, drugs, and cosmetics).

nonprescription drug

An over-the-counter medication.

nonsteroidal anti-inflammatory drug

Abbreviation: NSAID
A drug that has analgesic, anti-inflammatory, and antipyretic actions. NSAIDs are used to treat acute and chronic pain, e.g., of injuries, arthritis, and dysmenorrhea, to reduce inflammation, and to prevent complications in serious illness such as sepsis.

CAUTION!

All NSAIDS increase the risk of gastrointestinal bleeding and ulceration and, to some extent, the risk of renal failure, abnormalities in liver function, myocardial infarction, and stroke. These side effects occur most often in older patients, e.g., those with multiple risk factors for atherosclerotic vascular disease.

Many patients experience side effects of these medications, including upper gastrointestinal inflammation or bleeding. These side effects occur most often in the elderly, tobacco users, and those who drink alcohol. Other potential complications include acute and chronic renal failure, liver function abnormalities, and aseptic meningitis.

Members of this class of drugs include aspirin, ibuprofen, and naproxen.

Patient care

Patients who are sensitive to NSAID therapy are told to inform caregivers so that they will not be given NSAIDs. Patients are instructed to watch for adverse effects when taking NSAIDs and to report any gastrointestinal pain or bleeding. The patient should be cautioned not to take NSAIDs on an empty stomach but with milk, a meal, or an antacid. Skin should be protected from the sun. Pregnant women should avoid NSAIDs during their last trimester.

orphan drug

A drug effective for a certain illness but not profitable for manufacturers to produce.

performance-enhancing drug

Any drug used to gain an advantage in sports. Such drugs may improve endurance or strength or accelerate healing after injury.

pioneer drug

The brand-name or patented version of a drug, later copied to make generic drugs after the patent expires.

psychotherapeutic drug

A drug to improve the principal symptoms, e.g., anxiety, depression, and psychosis, in the mentally disturbed.

psychotropic drug

A drug that affects psychic function, behavior, or experience. Many drugs can be classed as intentionally psychotropic, but many other drugs also occasionally may produce undesired psychotropic side effects.

radioprotective drug

A drug that protects humans against the damaging or lethal effects of ionizing radiation. For example, Lugol's solution blocks the uptake of inhaled or ingested radioactive iodine by the thyroid.

recreational drug

A drug used for enjoyment rather than for a medical purpose.

scheduled drug

See: Controlled Substance Act

slow-acting antirheumatic drug

Abbreviation: SAARD
Disease-modifying antirheumatic drug.

soft drug

1. A drug that is easily metabolized by the body to inactive, nontoxic metabolites.
2. An illicit drug that has fewer psychoactive, addictive, or other adverse effects than a street drug orhard drug.
3. A drug that dissolves in the mouth and is quickly absorbed.

specialty drug

A drug that has unusually complex requirements for development, manufacturing, storage, transportation, administration and/or monitoring. Most drugs in this category are extraordinarily expensive.

street drug

A drug obtained illegally, usually a drug of abuse.

sulfa drug

Any drug of the sulfonamide group possessing bacteriostatic properties.

ulcerogenic drug

A drug, e.g., a nonsteroidal anti-inflammatory drug, that may cause peptic ulcers.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Oxford BioTherapeutics Ltd, a clinical stage oncology company, has received US Investigational New Drug approval from the Food and Drug Administration for OBT076, its experimental antibody drug conjugate for the treatment of women with high risk HER2 negative breast cancer and other solid tumours such as gastric, lung, bladder and ovarian cancer, it was reported yesterday.
I-MAB Biopharma Co Ltd, a Shanghai-based biotech company focused on innovative biologics in immuno-oncology and autoimmune diseases, and Genexine Inc (KOSDAQ: 095700), a South Korea-listed clinical stage pharma company developing innovative biologics, have received approval from the China National Medical Products Administration (NMPA) for the Investigational New Drug (IND) application for TJ107 (HyLeukin), claimed to be the first and only long-acting recombinant human interleukin-7 (rhIL-7) globally to treat chemotherapy induced lymphopenia and cancer, it was reported on Friday.
M2 PHARMA-November 12, 2018-Cancer Targeted Technology Files Investigational New Drug Application for CTT1403, a Novel Radiotherapeutic Drug for Prostate Cancer
M2 EQUITYBITES-October 8, 2018-US Food and Drug Administration approves Coordination Pharmaceuticals' Investigational New Drug application of CPI-100
This follows British Biotech's submission of an Investigational New Drug (IND) application on February 19 this year to conduct a Phase II clinical trial of the drug in acute myocardial infarction (AMI).
DiaMedica Therapeutics announced that the FDA has accepted DiaMedica's Investigational New Drug application ("IND") for the initiation of a Phase Ib clinical trial of DM199 in patients with moderate or severe Chronic Kidney Disease, or CKD, caused by Type I or Type II diabetes.
M2 PHARMA-November 5, 2018-I-MAB Biopharma Co and Genexine receive Chinese authority's approval for Investigational New Drug application of TJ107
M2 EQUITYBITES-September 18, 2018-US FDA approves Oramed Pharmaceuticals' Investigational New Drug application for human trials of ORMD-0901
The new study is intended to complement and extend the observations in the company's first Phase 1 trial, conducted in Israel under a US Food and Drug Administration Investigational New Drug Application with the approval of the Israel Ministry of Health.
Aimmune submitted its investigational new drug, or IND, application for AR201 for the treatment of egg allergy.
M2 PHARMA-October 8, 2018-US Food and Drug Administration approves Coordination Pharmaceuticals' Investigational New Drug application of CPI-100
Cancer immunotherapy specialist Immutep Ltd (ASX:IMM) (NASDAQ:IMMP) has submitted its Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) for eftilagimod alpha, also known as efti or IMP321, the company said on Monday.

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