INF2

(redirected from inverted formin, FH2 and WH2 domain containing)

INF2

A gene on chromosome 14q32.33 that encodes a diaphanous formin, which in mice plays a role in polymerisation and depolymerisation of actin filaments.

Molecular pathology
INF2 mutations are associated with focal segmental glomerulosclerosis type 5, as well as some cases of Charcot-Tooth-Marie neuropathy.
References in periodicals archive ?
As for the other CMT genes, the mutation frequency was 35.9% in peripheral myelin protein 22 gene, 17.4% in mitofusin 2 gene, 2.2% in myelin protein zero gene, 5.4% in inverted formin, FH2 and WH2 domain containing ( INF2 ) gene, 4.3% in ganglioside-induced differentiation associated protein 1 gene, 2.2% in neurofilament light gene, 2.2% in periaxin gene, 1.1% in SH3 domain and tetratricopeptide repeats 2 gene, 1.1% in early growth response 2 gene, 1.1% in glycyl-tRNA synthetase gene, 1.1% in leucine rich repeat and sterile alpha motif containing 1 gene, 1.1% in FIG4 phosphoinositide 5-phosphatase ( FIG4 ) gene, 1.1% in alanyl-tRNA synthetase gene, and 1.1% in dehydrogenase E1 and transketolase domain containing 1 gene.