inulin clearance


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Related to inulin clearance: creatinine clearance

in·u·lin clear·ance

an accurate measure of the rate of filtration through the renal glomeruli, because inulin filters freely with water and is neither excreted nor reabsorbed through tubule walls. Inulin is not a normal constituent of plasma and must be infused continously to maintain a steady plasma concentration and a steady rate of urinary excretion during the measurement. Inulin clearance in a normal adult person is about 120 mL/min (range, 100-150) per 1.73 m2 body surface area.

in·u·lin clear·ance

(in'yū-lin klēr'ăns)
An accurate measure of the rate of filtration through the renal glomeruli, because inulin filters freely with water and is neither excreted nor reabsorbed through tubule walls. Inulin is not a normal constituent of plasma and must be infused continously to maintain a steady plasma concentration and a steady rate of urinary excretion during the measurement.
References in periodicals archive ?
Practical approach for determining glomerular filtration rate by single- injection inulin clearance. Clin.
The p-aminohippuric acid clearance ([C.sub.PAH]) values, on estimation of renal plasma flow and glomerular filtration rate measured by inulin clearance ([C.sub.in]), did not change in our experiments (Table 1) at any concentration of steviol tested.
As expected for endogenous GFR markers, multiple linear regression analysis between the reciprocals of the LMW protein serum concentrations, and inulin clearance showed a highly significant positive relationship (Table 1).
The alternative reference methods to the gold standard inulin clearance are similar but not the same.
Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis.
The most precise and accurate methods (such as inulin clearance) are impractical in the clinical setting and for larger research studies.
For these reasons, renal inulin clearance is not routinely used in the clinical setting.
We also examined 27 pediatric patients [15 males (7-17 years) and 12 females (6-17 years)], in whom inulin clearance had been determined for nephrologic evaluation of a nephroblastoma or because they had received nephrotoxic drugs.
Inulin clearance ([C.sub.In]) [4] is regarded as the "gold standard" for evaluating glomerular filtration rate (GFR), but cost and technical difficulties preclude its routine use in clinical practice (1).
Among 41 normotensive elderly patients with no evidence of renal disease, 11 had GFRs determined by inulin clearance below the 95% reference interval, and all 11 of these patients had increased CysC but normal SCr (33).