The most characteristic feature of intussusceptive angiogenesis in tumor tissues is thought to be the development of protrusions or infoldings of the vessel wall within the lumen  (Figure 2).
Pillars, the hallmark of intussusceptive angiogenesis, develop within capillaries, small arteries, and veins and subsequently fuse, thus delineating new vascular entities or resulting in vessel remodeling .
Intussusceptive angiogenesis may have different outcomes depending on the location of the pillars, and different subtypes are named as follows: intussusceptive microvascular growth (IMG), which refers to the expansion of the capillary bed, and intussusceptive arborization (IAR) that describes the formation of the typical vascular tree, while intussusceptive branching remodeling (IBR) denotes vascular remodeling and adaptation to suit local perfusion requirements and includes intussusceptive vascular pruning (IVP).
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