intron

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Related to intronic: Intergenic

in·tron

(in'tron),
A portion of DNA that lies between two exons, is transcribed into RNA, but does not appear in that mRNA after maturation because the intron is removed and the exons spliced together, and so is not expressed (as protein) in protein synthesis. By customary usage, the term is extended to the corresponding regions in the primary transcript of mRNA before maturation.
[inter- + -on]
Farlex Partner Medical Dictionary © Farlex 2012

intron

(ĭn′trŏn)
n.
A segment of a gene situated between exons that is removed before translation of messenger RNA and does not function in coding for protein synthesis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

in·tron

(in'tron)
A portion of DNA that lies between two exons, is transcribed into RNA, but does not appear in that RNA after maturation, and so is not expressed (as protein) in protein synthesis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

intron

A non-coding segment of a DISCONTINUOUS GENE. Introns are lengths of DNA interposed between coding segments (EXONS) in a gene and are transcribed into MESSENGER RNA but are then removed from the transcript and the exons spliced together. Introns do not contain biological information.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

intron

or (‘in’ for intervening) - an intervening nucleotide sequence in an INTERRUPTED split gene. Such sequences are transcribed into primary RNA transcripts, but then excised from the RNA, leaving behind the EXON sequences for the functional gene product. See RNA PROCESSING, RNA SPLICING.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
It is also observed in the current results that Tp53 tumor suppressor gene is highly mutant especially in intronic regions.
Intronic single nucleotide polymorphic variant (SNP) rs1021261 in the LUZP2 gene resulted from the G-T transversion in the position 24660211 (human genome build GRCh38.p7) on chromosome 11.
Specifically, in our cohort, the most frequent mutation is the intronic splicing mutation IVS40+5G>A, accounting for 16.1% of all screened alleles (19/118).
A thorough review of the variant spectrum associated with each gene is essential to identify common pathogenic variants or hot spots and pathogenic variants located outside of typically covered exonic regions, such as deep intronic or untranslated regions.
Intronic elements in the [Na.sup.+]/[I.sup.-] symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription.
Several mutations identified in the MMR genes are missense, silent, or intronic variants.
A common intronic CSMD1 variant, rs10503253, was reported as genome-wide significant for SZ by Schizophrenia Psychiatric Genome-Wide Association Study Consortium [3] and was subsequently replicated in other GWA and meta-analysis studies [4-6].
Briefly, variants meeting the following criteria were filtered out: (1) variants covered by less than 10 sequencing reads; (2) intronic and synonymous variants; (3) variants with allele frequencies bellow 0.01 in 1000 genome database, ESP6500 database, or ExAC database.
On the other hand, the intronic c.1320+33T>C alteration might also be damaging by affecting splicing, as supported by previous studies reporting the pathogenic significance of similar intronic defects (reviewed in [26]).
A deep intronic mutation in OFD1 responsible for a severe form of X-linked RP was reported before [11].
MiRNAs are widespread throughout the genome, where they can be found in either intergenic or intragenic (especially intronic) regions [4].
Depending on their relationships with the neighboring protein-coding genes, the identified lncRNAs can be classified to six categories: (1) sense or (2) antisense, the lncRNA transcript overlaps one or more exons of another transcript in the same or opposite DNA strand, respectively; (3) bidirectional, expression of lncRNAs is in the same direction as a neighboring coding transcript in the same chain; (4) intronic, lncRNAs derive wholly from within an intron of a second transcript; (5) intergenic, lncRNAs lie within the genomic interval between two genes; (6) small RNA (sRNA) host lncRNA [7,28].