intravenous immune globulin


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Related to intravenous immune globulin: Intravenous immunoglobulin

intravenous immune globulin

A formulation of concentrated antibodies–aka immune globulins, predominantly IgG, prepared by pooling plasma from ±1000 donors, with a broad spectrum of activity against CMV, HAV, HBV, measles, rubella, tetanus, varicella zoster Indications LBW children with repeated infections, children with defects in humoral immune responses–eg, AIDS, X-linked agammaglobulinemia, CVID; IVIG may be of use in ITP, autoimmune phenomena–hemolysis, neutropenia, thrombocytopenia, Kawasaki's disease Adverse effects Pyrogenic, hypersensitivity, anaphylaxis, systemic–eg, headache, myalgia, fever, vasomotor and cardiovascular abnormalities, BP lability, tachycardia. Cf Human immune globulin.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

intravenous immune globulin

Abbreviation: IVIG, IGIV
An immune globulin preparation used intravenously in patients with immunodeficiency syndromes and in immunosuppressed recipients of bone marrow transplants. Together with aspirin, it is the standard of care for children during the first 10 days of Kawasaki disease to prevent the development of coronary aneurysms.

IVIG is also used to treat idiopathic thrombocytopenic purpura and Guillain-Barré syndrome as well as to prevent bacterial infections in patients with hypogammaglobulinemia or recurrent infections associated with B-cell chronic lymphocytic leukemia.

CAUTION!

The administration of sucrose-containing IVIGs has been associated with acute renal failure, which in about 10% of patients has proved fatal. Patients should be hydrated before being treated with IVIG.
See also: globulin
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The Guillain-Barre syndrome (GBS) is an acute monophasic illness causing a rapidly progressive polyneuropathy with weakness or paralysis.1 The main stay of therapy for GBS includes plasmaphoresis or administration of intravenous immune globulin.2 Both therapies are recommended for those patients who are unable to walk unaided, demonstrate worsening lung vital capacities and require mechanical ventilation who present within four weeks of symptom onset.
Intravenous immune globulin in the therapy of peripartum cardiomyopathy.
As with other intravenous immune globulin products, the infusion should be started slowly.
Treatment with intravenous immune globulin (IVIG, 400 mg/kg) was started on day 4 and given for 5 consecutive days, which resulted in marked and continued neurologic improvement.
Meta-analyses of the effectiveness of intravenous immune globulin for prevention and treatment of neonatal sepsis.
It is a specialty plasma-derived, polyclonal intravenous immune globulin, and includes naturally occurring polyclonal antibodies and high levels of antibodies targeted to respiratory syncytial virus or RSV.
1845, legislation to provide for a study on issues relating to access to intravenous immune globulin (IVIG) for Medicare beneficiaries.
ATLANTA -- Intravenous immune globulin should be the primary means of postexposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
ATLANTA -- Intravenous immune globulin should be the primary means of post-exposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
Among the factors favoring the use of intravenous immune globulin (WIG) for postexposure prophylaxis is the fact that it usually is in ample supply, although there have been some shortages in the past, said Philip LaRussa, M.D., of the division of pediatric infectious diseases, Columbia Presbyterian Medical Center, New York City.
Under the contract, Biotest Pharmaceuticals will offer manufacturing services and license proprietary fractionation and purification manufacturing process for Respiratory Syncytial Virus intravenous immune globulin to ADMA Biologics.

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