intravascular

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intravascular

 [in″trah-vas´ku-lar]
within a vessel or vessels.

in·tra·vas·cu·lar

(in'tră-vas'kyū-lăr),
Within the blood vessels or lymphatics.

intravascular

(ĭn′trə-văs′kyə-lər)
adj.
Within blood vessels or a blood vessel.

in′tra·vas′cu·lar·ly adv.

intravascular

adjective Within a blood vessel.

hemoglobinuria

Hematology The presence of Hb in the urine which, if of sufficient quantity, colors urine, the intensity of which directly correlates with the quantity of Hb. See Paroxysmal cold hemoglobinuria, Paroxysmal nocturnal hemoglobinuria.
hemolysis Destruction or lysis of RBCs
Hemolysis
Intracorpuscular hemolysis
•  Membrane defects, eg hereditary elliptocytosis, spherocytosis, stomatocytosis and paroxysmal nocturnal hemoglobinuria
•  Metabolic defects, eg G6PD, pyruvate kinase deficiency
•  Abnormal Hbs see Hemoglobin.
Extracorpuscular hemolysis
1º immune reactions, eg autoimmune hemolytic anemia
2º immune reactions, due to
• Infections, eg Bartonella, Clostridia, malaria, sepsis
• Neoplasia, eg lymphoma, leukemias
• Drug reactions due to the 'Innocent bystander' phenomenon (drug-antibody complex activates complement, causing intravascular hemolysis, eg quinidine), hapten-mediated —a protein-bound drug attaches to the red cell membrane, eliciting an immune response when the hapten-protein complex is recognized as foreign, evoking an immune response, eg penicillin acting as a hapten
• Induction of autoimmunity by RBC antigen alterations, eg Rh antigen
Physical, eg thermal, concentrated glycerol due to inadequate washing of frozen blood, bladder irrigation, cardiac valves
Extravascular Less severe, IgG-mediated and does not activate complement, eg Rh, Kell, Duffy Laboratory ↓ haptoglobin, ↓ T1/2 of circulating RBCs, ↑ indirect BR as liver capacity to conjugate BR–ergo direct BR is overwhelmed by massive hemolysis, ↑ LDH, Hb in blood and urine, hemosiderinuria, MetHb and metalbumin, ↑ urobilinogen in urine and feces, ↑ in acid phosphatase, K+, and prostatic acid phosphatase Clin Chem 1992; 38:575; peripheral smears demonstrate anisocytosis, polychromatophilia, nucleated RBCs, basophilic stippling; immune hemolysis is suggested by spherocytes NEJM 2000; 342:722cpc
Intravascular More severe, IgM-mediated and requires complement activation, eg ABO blood groups Laboratory ↑ free Hb  Note: Clinically significant hemolysis is usually detected by hemagglutination, less commonly by hemolysis per se, which detects anti-P,
-P1, -PP1Pk, -Jka, -Lea, occasionally also anti-Leb and -Vel

intravascular

Within a blood vessels within the lymphatics.

in·tra·vas·cu·lar

(IV) (in'tră-vas'kyū-lăr)
Within the blood vessels or lymphatics.
References in periodicals archive ?
However, limitations in generalizability of this study include that most patients (n = 44) underwent normothermia using surface cooling, only five patients were cooled intravascularly, direct skin temperature measurement was not assessed, and the effect of CW on core temperature was not discussed.
Thus the catechins found in the brain were located intracellularly or interstitially and not intravascularly.
Colloids are made up of larger molecules and are primarily distributed intravascularly. They have a rapid and sustained effect and a lesser amount is required for the same.
Up to 10% of epidural catheters may be initially inserted intravascularly, with up to 1% going undetected (1).
The drug may be injected into the myometrium--5 mg is added to 20 ml saline and 2 ml injected into various sites in the myometrium, being careful not to inject intravascularly. Alternatively 5 mg may be added to a litre of the crystalloid infusion.
Rats at PN 39,53 and 105 received EDs by road intravascularly (IV), rats at PN 57 and 92 received by road intramuscularly (IM) and rats PN 68,78 and 118 by road intraperitonial (IP).
(30,31), if an arbovirus were deposited intravascularly, it would quickly circulate beyond the bite site and animals with tail amputations would still become infected and die.
Intravascularly, microorganisms can originate from infected organs, cavities, fluids (e.g., cerebral spinal, synovial, or pericardial), untreated superficial wounds, abscesses, urinary tract infections, or respiratory infections.
Aspirate before slow injection of the solution to avoid injecting intravascularly.
Prior to the administration of a volume of anesthetic, it is essential to aspirate to ensure that the anesthetic is not delivered intravascularly, thereby, decreasing the occurrence of a toxic response.
Unlike standard vena cave filters, this filter is designed to be retrievable intravascularly for up to 10 days after deployment.
We are currently part of a research project involving a device that would allow us to control body temperature intravascularly, through a cooling pump.

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