intravascular large B-cell lymphoma

(redirected from intravascular lymphoma)

intravascular large B-cell lymphoma

A high-grade non-Hodgkin lymphoma arising in and generally confined to vascular lumina, which usually begins in the skin and CNS and rapidly spreads elsewhere.

Clinical findings
Often begins with fever of unknown origin and nonspecific cutaneous (e.g., plaques) and neurologic complaints.
 
DiffDx
Skin lesions (erythematous/purple plaques on the trunk and lower legs) may be confused with mycosis fungoides, sarcoidosis, vascular neoplasms (e.g., Kaposi sarcoma) or involvement by lymphoma or leukaemia.

Prognosis
Extremely poor; short survival is the norm despite aggressive chemotherapy. The diagnosis is often established postmortem.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Furthermore, there were no signs of hemophagocytosis, such as high fever, liver failure, or coagulopathy; clear evidence of intravascular lymphoma in the pathology was also not found.
Wiernik, "Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity," Annals of Hematology, vol.
Seymour et al., "Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'," British Journal of Haematology, vol.
Intravascular lymphoma masquerading as Vogt-Koyanagi-Harada syndrome Ocul Immunol Inflamm.
The vast majority of reported cases are in B-cell lineage lymphomas, and intravascular lymphoma involvement is rarely seen in T-cell lymphoma.
(42) However, the "other" category consists of rarer lesions that can be subcategorized into well-known morphologic entities: T-cell/histiocyte-rich large B-cell lymphoma (TC/HR LBCL), plasmablastic lymphoma, and intravascular lymphoma. The TC/HR LBCL of the skin has a better prognosis compared to its nodal/noncutaneous counterparts.
We present a rare case of intravascular lymphoma (IVL) presenting with FUO, severe PH, and disseminated lymphadenopathy diagnosed by random fat pad biopsy.
Intravascular lymphoma presenting as an orbital mass lesion: a case report.
Test results revealed intravascular lymphoma, a type of cancer.
There was a prominent component of large atypical cells within the dilated vascular channels (figure, A), which initially raised the possibility of an intravascular lymphoma or sarcoma.

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