The Phase 1 safety study, conducted at the Royal Victoria Eye and Ear Hospital in Melbourne, Victoria, Australia, enrolled 9 adult subjects with severe to profound sensorineural hearing loss who were scheduled to receive a cochlear implant in the 24 hours following intratympanic
injection of FX-322, to determine the safety and tolerability of FX-322 in the awake patient.
Safety and Efficacy of Intratympanic
Ciprofloxacin Otic Suspension in Children With Middle Ear Effusion Undergoing Tympanostomy Tuba Placement: Two Randomized Clinical Trials, JAMA Otolsryngol Head Neck Surg.
a) Fungal, eosinophilic, and tubercular otitis media and perforation after steroid intratympanic
The HEALOS trial is a randomised, double-blind, placebo-controlled study assessing the efficacy, safety and tolerability of single-dose intratympanic
administration of AM-111.
Patients with disorder of the middle ear, previous head trauma, administration of intratympanic
gentamicin injections, or those who have accepted cochlear implantation surgery were excluded from the study.
38) to compare the efficacy of oral prednisolone and intratympanic
methyl-prednisolone for the treatment of moderate-to-severe sensorineural hearing loss.
Furthermore, in a yet unpublished study, we found that while examining the effects of intratympanic
gentamycin injection on MD patient with or without migraine, migraines and vestibular migraines were triggered after chemical ablation of the vestibular system with gentamycin injections in several patients with migraine history but not in those without.
18,19] When intense attacks are frequent, more invasive procedures such as instillation of gentamicin or steroids via intratympanic
injection or a grommet may be considered or, very rarely, vestibular nerve section or labyrinthectomy.
Lidocaine has a long history of use for tinnitus, by both intravenous and intratympanic
The alteration of its function can changes the intratympanic
pressure and can generate tinnitus, vertigo, sensations of hearing loss of low tones, otic fullness.
All patients underwent intratympanic
placement of Gelfoam, packing of the external auditory canal, postoperative antibiotic prophylaxis, and postoperative elevation of the head at a 45[degrees] angle.