A male metastatic gastric cancer patient commenced escalating intratumoural
injections of efti into a stomach tumour in September 2017.
Bilateral anterior watershed infarction, systemic hypoperfusion or hypovolaemic shock,2 pontine and extrapontine myelinozis,4 closed head trauma,5 central nervous system metastases,6 bilateral intratumoural
haemorrhage,7 cervical cord contusion,8 cervical region metastases,9 spinal cord infarcts,10 cervical myelopathy,11 hereditary and sporadic ALS, Sjogren and HIV-associated motor neuron disease,12 bilateral brachial plexopathy13,14 and cyclosporin-dependent neurotoxicity15 are some of the etiologic factors presented in the literature for MIBS.
Appraisal of intratumoural
microvessel density, MIB-1 score, DNA content, and p53 protein expression as prognostic indicators in patients with locally confined renal cell carcinoma.
These results were published in the International Journal of Cancer, in an article titled, 'First-in-human study with intratumoural
administration of a CD40 agonistic antibody, ADC-1013, in advanced solid malignancies.'
budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients.
Prognostic value of intratumoural
vessel density in cutaneous mast cell tumors of the dog.
T cell phenotype/functional markers (CD4, CD8, GZMB, PD1, Foxp3, and T-bet), macrophage markers (CD14, CD68, CD163, and CD209), CD20, CD56, HLA class I, and EZH2 assessments were performed by the pathologist, while intratumoural
T lymphocyte infiltration (CD3 and CD8) was also analysed and scored using the "positive pixel count" algorithm of Aperio ImageScope (Version 12.1, Leica Biosystems, Wetzlar, Germany) after scanning of the whole tumour section.
Other theories document localization to increased expression of certain receptors on tumour cells, decreased intratumoural
pH, or tumour-associated macrophages that phagocytise PS molecules .
This maybe due to the underlying inter-and intratumoural
heterogeneity leading to intrinsic and/or acquired resistance to therapy, or to basic molecular pathways (such as angiogenesis) not controlled by these therapies.
Regions of interest (ROIs) of the targeted tumour (T) and the marker ([T.sub.mk]) were drawn to estimate the T/[T.sub.mk] ratio and intratumoural
effective half-life of [sup.32]P-CP.
Fischer et al., "Intratumoural
heterogeneity generated by Notch signalling promotes small-cell lung cancer," Nature, vol.
The progression of a tumour during carcinogenesis can be related to its intratumoural
hypoxia by up-regulating the CXCR4 expression in the tumour cells.