Within the prostate gland.
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Interestingly, following medical or surgical castration, the intraprostatic concentration of DHT is about 40% of that measured in the prostates of intact 65-yr-old men.
Uncertainty about the significance of serum testosterone determinations stem from the finding that they are a poor reflection of prostate tissue androgen levels, (2) but perhaps more confounding is the realization that following medical castration, there is a decrease of 94% in serum testosterone levels while intraprostatic testosterone and dihydrotestosterone remain at 20-30% of pre-castration levels.
To date, only 10 cases of intraprostatic synovial sarcoma have been reported in the literature.
sup][7] studied twenty prostate cancer patients treated using three or four intraprostatic gold fiducial markers.
However, the elevated serum or intraprostatic androgen levels may not be the causative factor in the activation of AR and etiology of BPH in humans, because the current literature lack conclusive data on serum or intraprostatic androgen levels, DHT in particular.
Concentration of ofloxacin in canine prostate tissue and prostate fluid after intraprostatic injection of biodegradable sustained releasing microspheres containing ofloxacin.
The intraprostatic injection of botulinum neurotoxin type A (BoNT-A) is a minimally invasive usage of the drug to treat benign prostatic hyperplasia (BPH) and subsequent lower urinary tract symptoms (LUTS).
However, despite the efficiency of clinical staging, it remains imperfect for precise local cancer staging and intraprostatic tumor localization, both of which play important roles in initial assessment, treatment, and, in many cases, follow-up.
Recently it has been determined whether SeMet or Se-Yeast acts with different potency on six biochemical markers including intraprostatic dihydrotestosterone (DHT), testosterone (T), DHT:T, and epithelial cell DNA damage, proliferation, and apoptosis (Waters et al.
However, in 94% of tumors, ADC was in exact concordance with the most aggressive tumor composition despite the fact that the DW-MRI value was less in few cases of severe motion artifacts, widespread intraprostatic hemorrhage, or ghosting artifacts on the MR images.
The new study will enroll 100-200 subjects who had previously participated in an NX-1207 BPH study and will involve a second treatment of intraprostatic NX-1207 2.