In the APOLLO study for the treatment of recurrent ovarian cancer, one subject treated with a single intraperitoneal infusion
of FATE-NK100 at the second dose level had stable disease at one month.
(4) Three groups were identified: Group A (n=30) postoperative intraperitoneal infusion
of a mixture of 10 ml of 0.5% bupivacaine (50 mg) with epinephrine (1:500) in 40ml Ringer's lactated solution, Group B (n=30) the same mixture solution infused IP pre- and post- hysterectomy (total 100 mg bupivacaine), and Group C (n=31) placebo.
Diabetes mellitus was induced by a single intraperitoneal infusion
of streptozotocin (Sigma, USA) in a dose of 60 mg/kg dissolved in 0.01mol/L citrate buffer (pH 4.5) .
The dogs from the CT group received no intraperitoneal infusion
. The abdominal wall was closed using an interrupted cross mattress pattern, with 2-0 polyglycolic acid thread.
In second experiment, the chronic intraperitoneal infusion
of BQ123 was used to observe the effect of BQ123 on FAP and PAP in broiler chickens with long-term adaptation to antagonism.
You may experience some discomfort during the intraperitoneal infusion
of streptokinase in the treatment of recurrent peritonitis.
Dose-limiting toxicities were observed only in patients with ovarian cancer who received tgDCC-E1A by intraperitoneal infusion
; subsequent changes to the procedure for making the final patient preparation are expected to reduce these toxicities.
Additionally, the Day 28 response evaluation for Subject 2 following a single intraperitoneal infusion
of NK100 showed stable disease with evidence of tumor reduction.
The multi-centre, non-randomised, open label, dose-escalation Phase I clinical trial will evaluate the safety and effectiveness of intraperitoneal infusions
of MCY-M11 in individuals with platinum-resistant high-grade serous adenocarcinoma of the ovary, primary peritoneum or fallopian tube, or individuals with advanced peritoneal mesothelioma with recurrence after prior chemotherapy.