intraperitoneal chemotherapy

intraperitoneal chemotherapy

The administration of chemotherapeutic agents direct into the peritoneal cavity. A form of administration of paclitaxel and cisplatin delivered in warmed saline through an implantable peritoneal catheter used in patients with debulked stage III ovarian cancer. This route has been found superior for improving survival to the same drugs given intravenously.
References in periodicals archive ?
This surgery concluded with a technique called Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and a further four days of intraperitoneal chemotherapy.
5,8 However, an aggressive cytoreductive surgery and a perioperative intraperitoneal chemotherapy with Mitomycin-C and 5-fluorouracil could be used for appendiceal cancers with peritoneal disseminations.
Our patient with metachronous KT will undergo laparoscopy and hyperthermic intraperitoneal chemotherapy and our patients with synchronous KT will continue to be followed up to determine their final outcomes.
He has extensive training in novel surgical techniques, including in hyperthermic intraperitoneal chemotherapy, or HIPEC, which is a highly concentrated, heated chemotherapy treatment that is delivered directly to the abdomen during surgery.
It is important to note, however, that side effects such as abdominal pain, nausea, and vomiting are often more severe with intraperitoneal chemotherapy than with intravenous chemotherapy alone.
Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy.
Hyperthermic intraperitoneal chemotherapy (HIPEC) may be an alternative to reduce or avoid this recurrence.
The cancer expert specializes in combining cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of gastrointestinal tumors that have spread throughout the abdominal cavity.
The results of the largest study which included 405 patients showed a 3 and 5 years survival rates of 60 and 47%, the best prognostic factors being: the epithelioid subtype, the absence of lymph nodes metastasis, optimal cytoreduction and the hyperthermic intraperitoneal chemotherapy [17].
2) Treatment of PMP is usually performed with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), with varying degrees of success and associated morbidity.
New surgical options are emerging for selected patients with recurrent ovarian cancer, such as complete cytoreductive surgery including peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC).
National Cancer Institute, NCI Clinical Announcement: Intraperitoneal chemotherapy for ovarian cancer, Bethesda MD: NCI, January 6, 2006.