IORT

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IORT

Abbreviation for intraoperative radiation therapy.

radiation therapy

,

RT, XRT

The use of energy from man-made ionizing radiation or from the radioactive decay of atomic nuclei to destroy diseased tissues, esp. cancers. Synonym: radiotherapy

Patient care

The radiotherapy must be directed only at the diseased tissue. The patient's body is precisely measured and marked (“tatooed”), and cradles are designed to hold the patient in a precise position for each treatment. Systemic adverse effects of radiation therapy include weakness, fatigue, anorexia, nausea, vomiting, and anemia. These may subside with antiemetics, steroids, frequent small meals, fluid maintenance, and added rest and are seldom severe enough to require discontinuation of treatment although dosage adjustment may be required. Local adverse effects of radiation depend on the organ system affected. For example, radiation of the breast may sometimes result in esophagitis or pneumonitis; cranial radiation may cause hair loss; radiation treatment of head and neck cancers may cause dry mouth (for which good oral hygiene or artificial saliva may be helpful). Because radiation may affect bone marrow, patients require frequent measurement of complete blood counts. Radiation also requires special skin care, and the patient should use a hypoallergenic moisturizer (Biafine, Radiacare Gel, and Aquaphor are popular brands). Many nurses and patients prefer using natural aloe (from the leaf of an aloe plant, split open to apply the gel from inside) or bottled aloe. Usually the radiation therapist will recommend that the skin be free of any such preparations at treatment time.

conformal radiation therapy

Radiation therapy in which tumors are imaged in three-dimensions and then treated with small beams of radiation adjusted for their size, unique shape, and location. The objective is to deliver the radiation directly to the tumor and to make the energy conform to the unique shape of the tumor, leaving neighboring healthy tissue unaffected by the damaging effects. This therapy is used to treat tumors previously treated with external beam radiotherapy, tumors for which external beam radiation is also planned, and tumors that are difficult to reach or that have encircled healthy organs or tissues. Synonym: intensity-modulated radiation therapy

endocavitary radiation therapy

Intracavitary radiation therapy.

intensity-modulated radiation therapy

Abbreviation: IMRT.
Conformal radiation therapy.

intracavitary radiation therapy

Radiation therapy for treatment of a cancer found in hollow organs (such as the rectum, the sinuses, or the vagina) by placing the source of radiation inside the affected body cavity.
Synonym: endocavitary radiation therapy

intraoperative radiation therapy

Abbreviation: IORT
The administration of a large dose of radiation to a malignant tumor during surgery. After the tumor is debulked, the surrounding tissues are displaced, temporarily sutured, or protected by the applicator shield. The applicator then delivers a large dose of radiation directly to the affected tissues. IORT is used to manage otherwise unresectable tumors.

involved-field radiation therapy

A treatment for lymphoma in which therapeutic radiation is directed only to those areas involved by detectable tumor masses and not to other regions of the body

selective internal radiation therapy

Abbreviation: SIRT
The treatment of solid internal organ tumors with radioactive microspheres injected directly into the target tissue, or bound to substrates that the target tissue preferentially takes up from the blood.
Synonym: radioembolization; selective internal radiotherapy

intraoperative radiation therapy

Abbreviation: IORT
The administration of a large dose of radiation to a malignant tumor during surgery. After the tumor is debulked, the surrounding tissues are displaced, temporarily sutured, or protected by the applicator shield. The applicator then delivers a large dose of radiation directly to the affected tissues. IORT is used to manage otherwise unresectable tumors.
References in periodicals archive ?
Supply of a mobile electron accelerator equipment for intraoperative radiotherapy treatments to the Ramn y Cajal University Hospital.
There are 2 phase III randomized trials investigating the efficacy of intraoperative radiotherapy compared with whole breast radiation.
The TARGIT-A study compared standard whole-breast radiation to single-dose intraoperative radiotherapy using the Zeiss Intrabeam technology.
At a median follow-up of 5.8 years, the in-breast recurrence occurred in 0.4 % in the external beam radiotherapy arm and in 4.4 % in the intraoperative radiotherapy arm, which was within the pre specified equivalence margin, and with no difference in 5-year overall survival (96.8 % and 96.9 %, respectively).
Abbreviations ASTRO: American Society for Radiation Oncology BCT: Breast conservation therapy EBRT: External beam radiotherapy ELIOT: Intraoperative radiotherapy versus external radiotherapy for early breast cancer trial GEC-ESTRO: Groupe Europeen de Curietherapie and the European Society for Radiotherapy and Oncology Gy: Gray IBTR: Ipsilateral breast tumor recurrence IORT: Intraoperative radiotherapy kV: Kilovoltage LR: Local recurrences PB: Partial breast irradiation PM: Partial mastectomy QOL: Quality of life RT: Radiotherapy TARGIT: Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer trial.
Maisonneuve et al., "Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomized controlled equivalence trial," The Lancet Oncology, vol.
Tobias et al., "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomized, non-inferiority phase 3 trial," The Lancet, vol.
Tobias, "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, noninferiority phase 3 trial," The Lancet, vol.
Luini et al., "A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated," European Journal of Cancer, vol.
Apffelstaedt, "7-year follow up of intraoperative radiotherapy for early breast cancer in a developing country" Breast, vol.
Each trial compared a different type of single intraoperative radiotherapy with external whole-breast irradiation.
In the ELIOT trial, 1305 patients were randomised after quadrantectomy to receive either whole-breast irradiation (50 Gy in 25 fractions followed by a boost of 10 Gy in five fractions using an external electron beam without node irradiation) or single intraoperative radiotherapy with electrons (21 Gy in one fraction to the tumour bed using electrons of 6-9 MeV).

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