The publication entitled, "Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection," details the preclinical study exploring the neuroprotective effects of daily and twice daily intranasally
delivered ST266 to evaluate different treatment regimens an EAE-induced experimental ON mouse model.
Because INKV induced limited disease in adult mice, we inoculated weanling mice intranasally
with INKV to determine if neuropathogenicity was age dependent.
administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
Study drug was administered intranasally
after a 2-hour baseline sampling period.
Mice were inoculated intranasally
with a single, nonlethal dose of the IAV PR8 strain (300 pfu).
Early exposure to morphine was slightly higher and early exposure to M6G was lower for crushed intranasal Morphine ARER than for intact oral Morphine ARER, which may be because of both the route of administration and an apparent reduction in overall bioavailability of intranasally
administered Morphine ARER.
Louis, MO) which has been used to boost the mucosal immunogenicity (5 [micro]g/25 [micro]l of ground leaf materials as described below) were then intranasally
inoculated into the nasal cavities of ICR mice (25 [micro]l of ground leaf materials).
Infiltration of the local anesthetic solution (2% lidocaine and 1:100,000 epinephrine) was made intranasally
and at the level of the lateral nasal walls.
Mice in Sp group were intranasally
inoculated with Sp (1x109 CFU/ml, 50 u l/mouse) and PBS group was inoculated with PBS intranasally
Among children living with IHO workers, 14% and 23% carried MRSA and MDRSA intranasally
, respectively, compared with 6% and 8% of CR children (Table 2).
In this time interval, the patient was no longer on a fixed schedule of desmopressin (ranging between 8 [micro]g intravenously and 10 [micro]g intranasally
To determine virus infectivity and neuroinvasion, mice were lightly anesthetized with ether and inoculated intranasally
with 50 [micro]l of phosphate-buffered saline (PBS) containing [10.sup.6] [EID.sub.50] of either LAIV, MDV, or SA/wt, divided equally between the nostrils.