intramuscular injection

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2. the forcing of a liquid into a part, as into the subcutaneous tissues, the vascular tree, or an organ.
3. a substance so forced or administered; in pharmacy, a solution of a medicament suitable for injection.

Immunizing substances, or inoculations, are generally given by injection. Some medicines cannot be given by mouth because chemical action of the enzymes and digestive fluids would change or reduce their effectiveness, or because they would be removed from the body too quickly to have any effect. Occasionally a medication is injected so that it will act more quickly. In addition to the most common types of injections described below, injections are sometimes made into arteries, bone marrow, the spine, the sternum, the pleural space of the chest region, the peritoneal cavity, and joint spaces. In sudden heart failure, heart-stimulating drugs may be injected directly into the heart (intracardiac injection).
Sites for injections. A, subcutaneous injection sites. B, intramuscular injection site for children in the vastus lateralis muscle. C, D, and E, intramuscular injection sites for adults: C, deltoid muscle injection site. D, injection site in the buttock (dorsogluteal site). E, injection site in the anterolateral thigh (ventrogluteal site).
hypodermic injection subcutaneous injection.
intracutaneous injection intradermal injection.
intracytoplasmic sperm injection (ICSI) a micromanipulation technique used in male factor infertility; a single spermatocyte is inserted into an oocyte by micropuncture.
intradermal injection injection of small amounts of material into the corium or substance of the skin, done in diagnostic procedures and in administration of regional anesthetics, as well as in treatment procedures. In certain allergy tests, the allergen is injected intracutaneously. These injections are given in an area where the skin and hair are sparse, usually on the inner part of the forearm. A 25-gauge needle, about 1 cm long, is usually used and is inserted at a 10- to 15-degree angle to the skin.
intramuscular injection injection into the substance of a muscle, usually the muscle of the upper arm, thigh, or buttock. Intramuscular injections are given when the substance is to be absorbed quickly. They should be given with extreme care, especially in the buttock, because the sciatic nerve may be injured or a large blood vessel may be entered if the injection is not made correctly into the upper, outer quadrant of the buttock. The deltoid muscle at the shoulder is also used, but less commonly than the gluteus muscle of the buttock; care must be taken to insert the needle in the center, 2 cm below the acromion.

Injections into the anterolateral aspect of the thigh are considered the safest because there is less danger of damage to a major blood vessel or nerve. The area permits multiple injections, is more accessible, and is easier to stabilize, particularly in pediatric patients or others who are restless and uncooperative. The vastus lateralis muscle is located by identifying the trochanter and the side of the knee cap and then drawing a visual line between the two. The distance is then divided into thirds and the needle inserted into the area identified as the middle third.

The needle should be long enough to insure that the medication is injected deep into the muscle tissue. The gauge of the needle depends on the viscosity of the fluid being injected. As a general rule, not more than 5 ml is given in an intramuscular injection for an adult. The maximum for an infant is 0.5 ml, and the injection is made into the vastus lateralis muscle. The needle is inserted at a 90-degree angle to the skin. When the gluteus maximus muscle is the site chosen for the injection, the patient should be in a prone position with the toes turned in if possible. This position relaxes the muscle and makes the injection less painful.
intrathecal injection injection of a substance through the theca of the spinal cord into the subarachnoid space. Patients receiving intrathecal chemotherapy for metastatic malignancy of the central nervous system should maintain a flat or Trendelenburg position for one hour after treatment to achieve optimum distribution of the drug.
intravenous injection an injection made into a vein. Intravenous injections are used when rapid absorption is called for, when fluid cannot be taken by mouth, or when the substance to be administered is too irritating to be injected into the skin or muscles. In certain diagnostic tests and x-ray examinations a drug or dye may be administered intravenously. (See also intravenous infusion.)
jet injection injection of a drug in solution through the intact skin by an extremely fine jet of the solution under high pressure.
subcutaneous injection injection made into the subcutaneous tissues. Although usually fluid medications are injected, occasionally solid materials such as steroid hormones may be injected in small, slowly absorbed pellets to prolong their effect. Subcutaneous injections may be given wherever there is subcutaneous tissue, usually in the upper outer arm or thigh. A 25-gauge needle about 2 cm long is usually used, held at a 45-degree angle to the skin, and the amount injected should not exceed 2 ml in an adult. Subcutaneous insulin injections may be given at a 90-degree angle with an insulin syringe. Called also hypodermic injection.
Angle of needle insertion for administering a subcutaneous injection. From Lammon et al., 1995.
Z-track injection see z-track injection.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

in·tra·mus·cu·lar in·jec·tion

(IMI) (in'tră-mŭsk'yū-lăr in-jek'shŭn)
Injection of fluid into deep muscle. Usual sites for intramuscular injections include ventrogluteal, vastus lateralis, and deltoid muscles. Absorption is faster than subcutaneous and up to 3 mL can be given by this method.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
By 12 weeks after treatment, complete healing of the lesions had occurred in 75% of patients who received intralesional injections, 69% of those treated with localized heat, and 49% of those treated with intramuscular injections, Dr.
Intramuscular injection technique: an evidence-based approach.
The average score on the knowledge questionnaire revealed that the lowest percentage of correct answers was given to the items related to the technique of giving an intramuscular injection (items number 19 and number 22).
Her relatives referred an intramuscular injection of ceftriaxone in the same site 8 days before for an upper respiratory tract infection.
This report describes 2 premature infants who developed an abscess after receiving their first infant vaccination in the form of an intramuscular injection; to our knowledge, these are the first such cases reported in premature infants.
[9.] Hasanpour, M., Tootoonchi, M., Aein, F., Yadegarfar, G., (2006)."The Effect Of Two Nonpharmacologic Pain Management Methods For Intramuscular Injection Pain In Children" Acute Pain, 8 (7-12)
Levels of blood glucose achieved and the time to reach the primary outcome were on par with those seen with intramuscular injection of glucagon, Dr.
"We are unable to exclude the possibility that the deaths were caused by rapid, but delayed, entry of the drug into the bloodstream following intramuscular injection," the FDA announced March 23.
Intramuscular injection is used as a technique of choice for application of drugs in many treatment protocols in order to achieve quick and effective response.
Granulocyte colony-stimulating factor (GCSF) is an expensive prescription drug administered by intramuscular injection under the care of a physician experienced in using the drug.
Nicolau syndrome (livedoid dermatitis) is a rare complication of intramuscular injection. It was first reported following intramuscular injection of bismuth salt, but can occur as a complication of various other drugs such as nonsteroid anti-inflammatory drugs, corticosteroids, local anesthetics and interferon alpha.
Leung and his associates measured hemaggluti-nation inhibition antibody (HIA) titers at baseline and 28 days post vaccination in 223 subjects with AD (including a subset with Staphylococcus aureus colonization) and 135 nonatopic controls after administration per label of either a single dose of the seasonal 2012-2013 intradermal Fluzone or Fluzone for intramuscular injection.