localization and release of rat liver superoxide dismutase.
Grossi et al., "A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial
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However, when the intramitochondrial
[Ca.sup.2+] concentration exceeds its buffering capacity, irreversible swelling occurs leading to mitochondrial dysfunction.
Ultrastructural examination on muscle confirmed the mitochondrial alterations with mitochondrial hyperplasia and ring cristae, intramitochondrial
lipid inclusion, and mitochondria with transversal orientation to the myofiber (Figure 2).
Evidence for intramitochondrial
peroxynitrite formation," Journal of Biological Chemistry, vol.
Thus, some particular polyphenols are now recognized as molecules capable of modulate pathways that define mitochondrial biogenesis (i.e., inducing sirtuins), mitochondrial membrane potential (i.e., mitochondrial permeability transition pore opening and uncoupling effects), mitochondrial electron transport chain and ATP synthesis (i.e., modulating complex I to V activity), intramitochondrial
oxidative status (i.e., inhibiting/inducing ROS formation/removal enzymes), and ultimately mitochondrial-triggered cell death (modulating intrinsic apoptosis) (review in ).
Metronidazole decreases exogenous [H.sub.2]S production by intestinal flora, and N-acetylcysteine replenishes intramitochondrial
glutathione stores in an effort to neutralize the oxidative injury from [H.sub.2]S accumulation.
fibers with DNA characteristics I.
Changes in intramitochondrial
and cytosolic pH: early events that modulate caspase activation during apoptosis.
Reed, "Changes in intramitochondrial
and cytosolic pH: early events that modulate caspase activation during apoptosis," Nature Cell Biology, vol.
macromolecular concentrations reach up to 560 g/L [20, 21].
Kadenbach, "Regulation of the H+/estoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial
ATP/ADP ratios," FEBS Letters, vol.