Within the mitochondria.
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References in periodicals archive ?
Grossi et al., "A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels," Cellular and Molecular Life Sciences, vol.
However, when the intramitochondrial [Ca.sup.2+] concentration exceeds its buffering capacity, irreversible swelling occurs leading to mitochondrial dysfunction.
Ultrastructural examination on muscle confirmed the mitochondrial alterations with mitochondrial hyperplasia and ring cristae, intramitochondrial lipid inclusion, and mitochondria with transversal orientation to the myofiber (Figure 2).
Evidence for intramitochondrial peroxynitrite formation," Journal of Biological Chemistry, vol.
Thus, some particular polyphenols are now recognized as molecules capable of modulate pathways that define mitochondrial biogenesis (i.e., inducing sirtuins), mitochondrial membrane potential (i.e., mitochondrial permeability transition pore opening and uncoupling effects), mitochondrial electron transport chain and ATP synthesis (i.e., modulating complex I to V activity), intramitochondrial oxidative status (i.e., inhibiting/inducing ROS formation/removal enzymes), and ultimately mitochondrial-triggered cell death (modulating intrinsic apoptosis) (review in [102]).
Metronidazole decreases exogenous [H.sub.2]S production by intestinal flora, and N-acetylcysteine replenishes intramitochondrial glutathione stores in an effort to neutralize the oxidative injury from [H.sub.2]S accumulation.
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis.
Reed, "Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis," Nature Cell Biology, vol.
Intramitochondrial macromolecular concentrations reach up to 560 g/L [20, 21].
Kadenbach, "Regulation of the H+/estoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial ATP/ADP ratios," FEBS Letters, vol.
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