intramembranous bone formation

intramembranous bone formation

Bone formation that occurs without a prior cartilage model, which contrasts to enchondral ossification.

Examples
Embryonic flat bone formation—e.g., skull, maxilla, mandible, pelvis, clavicle, subperiosteal surface of long bone; distraction osteogenesis bone formation; blastem bone (occurs in children following amputations); fracture healing with rigid fixation (e.g., with a compression plate); may occur as a component of healing with intramedullary nailing.

Defects in intramembranous bone formation
Caused by mutation in RUNX2 located on chromosome 6.

Steps of intramembranous bone formation
• Aggregation of undifferentiated mesenchymal cells;
• Osteoblast differentiation;
• Organic matrix deposition.
References in periodicals archive ?
The long bones are abnormally widened as a result of normal intramembranous bone formation in the context of disturbed endochondral ossification.
We have already shown that intermittent low-dose treatment with rhPTH(1-34) can increase hard callus formation (callus formed by intramembranous bone formation in periosteal osteoblasts and osteoprogenitor cells) and its mechanical strength without apparent systemic side-effects (Chang et al.
Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling.
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