intrahepatic cholestasis of pregnancy


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intrahepatic cholestasis of pregnancy

intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and icterus; of unknown cause but associated with high estrogen levels.

in·tra·he·pat·ic cho·le·sta·sis of preg·nan·cy

(in'tră-hĕ-pat'ik kō'lē-stā'sis preg'năn-sē)
Intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and/or icterus; of unknown cause but associated with high estrogen levels.
Synonym(s): cholestasis of pregnancy, recurrent jaundice of pregnancy.

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis
See also: cholestasis
References in periodicals archive ?
Mattsson, "Intrahepatic cholestasis of pregnancy: A randomized controlled trial comparing dexamethasone and ursodeoxycholic acid," Hepatology, vol.
Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-associated liver disease,1 and its incidence varies widely among various reports.
Prevalence of intrahepatic cholestasis of pregnancy in Chile.
Romagnoli, "Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome," Pediatrics, vol.
Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays, l Perinat Med.
Is a lecky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy? Hepatology, 43(4), 715-722.
VIENNA -- An elevated serum bile acid level is a highly reliable indicator of intrahepatic cholestasis of pregnancy in a woman who presents with itching and excoriated skin lesions late in gestation, Christina M.
She said: "My baby was delivered early because I developed a liver condition called ICP (intrahepatic cholestasis of pregnancy).
* Intrahepatic Cholestasis of Pregnancy (ICP), also known as cholestasis of pregnancy, recurrent jaundice of pregnancy or pruritus gravidarum.
Keywords: Atopic eruptions, intrahepatic cholestasis of pregnancy, polymorphic eruptions, pemphigoid gestationis, pregnancy-induced dermatoses.
Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Expert Rev Mol Med 2008; 10:e9.