intraepithelial carcinoma


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car·ci·no·ma in si·'tu (CIS),

a lesion characterized by cytologic changes of the type associated with invasive carcinoma, but with the pathologic process limited to the lining epithelium and without histologic evidence of extension to adjacent structures; the distinctive changes are usually more apparent in the nucleus, that is, variation in size and shape, increase in chromatin, and numerous mitoses (including some that are atypical) in all layers of the epithelium, with loss of orderly maturation. The lesion is presumed to be the histologically recognizable precursor of invasive carcinoma, that is, a localized and curable phase of carcinoma.

intraepithelial carcinoma

intraepithelial carcinoma

(1) Carcinoma in situ. 
(2) Intraepithelial neoplasia.
References in periodicals archive ?
TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions.
Uterine serous carcinomas frequently metastasize to the fallopian tube and can mimic serous tubal intraepithelial carcinoma.
Caption: Hematoxylin-eosin-stained sections of serous tubal intraepithelial carcinoma (STIC)-like lesion in fallopian tube (A) with concomitant endometrial endometrioid carcinoma (B).
For many decades it was assumed that HGSCs arise from the ovarian surface epithelium, but in 2001 this line of thinking was challenged by the identification of presumptive HGSC precursors--that is, serous tubal intraepithelial carcinomas (STICs), and occult HGSCs in the fallopian tubes of patients with germline BRCA1 mutations who were undergoing prophylactic surgery.
By applying the criteria used to classify ovarian mucinous cystic neoplasms, these areas were designated as foci of intraepithelial carcinoma, on the basis of the presence of severe cytologic atypia.
They contrast with the largely intracystic growth seen in our case whose spectrum, for the same lesion, ranged from cystadenoma to a borderline lesion to intraepithelial carcinoma, much like ovarian mucinous tumors.
On the basis of our experience in this case, and from what we can learn from descriptions and illustrations of prior published cases, tumors similar to the one seen in our case have a distinctive morphology and are best classified by applying the nomenclature used for ovarian neoplasms: cystadenoma, borderline mucinous tumor with or without intraepithelial carcinoma, and cystadenocarcinoma.
14-16) Figure 3, A and B, illustrates a typical example of a small focus of endometrial intraepithelial carcinoma in an atrophic curettage specimen.
As with other endometrioid adenocarcinomas, adjacent benign endometrium associated with the villoglandular type is often hyperplastic, while endometrium adjacent to serous carcinoma is usually atrophic and often reveals endometrial intraepithelial carcinoma.
55,56) This term has been used in recent publications to combine the noninvasive lesion endometrial intraepithelial carcinoma (14-16) and small (less than 11 mm in one report) superficially invasive serous carcinomas limited to the endometrium.
Endometrial intraepithelial carcinoma with associated peritoneal carcinomatosis.
Therefore, for colorectal cancer, the terms intraepithelial carcinoma and intramucosal carcinoma are recommended as descriptive terms to subclassify pTis and to clarify the status of the tumor.