Although many of these appear like any other nevus, approximately half are characterized by atypical features within the intraepidermal
component, including a lentiginous growth pattern, poor circumscription, irregular distribution of nests, and suprabasal scatter of melanocytes (Figure 4, B).
The non-tumorigenic radial growth phase encompasses the intraepidermal
lesions, namely lentigo maligna and in situ melanoma (M), and the microinvasive forms including ultra-thin M and the vast majority of thin M.
Caption: Figure 2: Histopathology study (hematoxylin and eosin staining) demonstrated pseudoepitheliomatous hyperplasia of epidermis with eosinophilic spongiosis (a), intraepidermal
eosinophilic microabscess with few acantholytic cells (b), and focal area of suprabasal separation (c).
Caption: Figure 4: An ulcerative lesion with a fibrinous cap and intraepidermal
vesicles (H&E x40).
Lesional infiltrates in GBFDE had more dermal CD4+ cells including [Foxp3.sup.+] cells, less intraepidermal
CD56+ cells, and fewer intraepidermal
[granulysin.sup.+] cells compared to those in SJS/TEN.
Breslow thickness Essential Surgical margin/tissue edge status Essential Ulceration Essential Mitotic count Essential Satellites Essential Lymphovascular invasion Essential Desmoplastic melanoma component Essential Neurotropism Essential Extent of ulceration Recommended Clark level Recommended Tumour-infiltrating lymphocytes Recommended Tumour regression Recommended Tumour regression margins Recommended Associated melanocytic lesion Recommended Intraepidermal
melanoma growth pattern Recommended Melanoma subtype Recommended
As a consequence, ESC reflects the density of intraepidermal
nerve fibers (IENF): low ESC is related to reduction in IENF density .
squamous carcinoma (Bowen's disease) of the nipple," Human Pathology, vol.
ahSGs are composed of four segments: intraepidermal
duct, straight intradermal duct, coiled intradermal duct, and secretory portion (Figure 1(a)).
Biopsy of the scalp lesion (Figure 4) revealed prominent intraepidermal
atypical melanocytes with pagetoid spread, as well as the presence of well-formed junctional melanocytic nests, characteristic for malignant melanoma with superficial spreading pattern and stained positive for S-100 and S0X-10.
The introduction of the minimally invasive technique of skin biopsy with determination of intraepidermal
nerve fiber (IENF) morphology provides an opportunity for the quantitative assessment of the treatment .
It has been demonstrated that intraepidermal
CD8+T cells with an effector-memory phenotype residing in FDE lesions have a major contributing role in the genesis of localized tissue damage.