Examples of immunohistochemistry in intraductal papilloma
with florid usual ductal hyperplasia (A through D), intraductal papilloma
with sclerosis (E through H), and adenomyoepithelioma (I through L; the arrow indicates a mitotic figure in [J]) (hematoxylin-eosin, original magnifications x40 [A, E, and I] and x400 [B and J]; CK5, original magnifications x400 [C and K] and X200 [F]; p63, original magnifications x400 [D and L] and X200 [G]; calponin, original magnification x400 [H]).
Results of excisional biopsies showed 1 case of invasive lobular carcinoma and 1 intraductal papilloma
Benign 69% Malignant 21% Benign query representative 10% Note: Table made form pie chart
Magnetic resonance imaging of intraductal papilloma
of the breast.
KEYS WORDS: Nipple Discharge, Breast Intraductal Papilloma
, Duct Ectasia, Microdochectomy, Ductal Carcinoma In Situ (DCIS), Lobular Carcinoma In Situ LCIS.
Features were consistent with intraductal papilloma
of salivary gland
Although the differential diagnosis includes intraductal papilloma
, especially when complicated by superimposed neoplastic proliferations, (136) such lesions are usually confined to one duct and its branches, rather than the multiductal distribution of papillary DCIS.
The densely cellular neoplastic cells often appear to be streaming, and thus may be mistaken for intraductal papilloma
with florid ductal hyperplasia.
Histologic examination made the diagnosis of intraductal papilloma
with focal atypia (Figure 3).
Wei discusses the histologic, immunohistochemical, and prognostic features of papillary lesions, including the intraductal papilloma
, papilloma harboring atypical ductal hyperplasia and ductal carcinoma in situ (DCIS), intraductal papillary carcinoma (papillary DCIS), encapsulated papillary carcinoma, solid papillary carcinoma, and invasive papillary carcinoma.
Benign intraductal papilloma
is a solitary lesion of the duct that typically presents when small and nonpalpable because of the occurrence of spontaneous nipple discharge.
In the assessment of atypical papillary lesions (ADH/DCIS involving benign intraductal papilloma
or papillary DCIS), immunohistochemical evaluation of the expression of HMWCK is a valuable adjunct, in which benign papillary lesions exhibit strong, mosaic reactivity throughout the lesion in 88% to 100% of cases, and atypical papillary lesions are nonreactive, indicating a clonal proliferation of luminal epithelial cells in 80% to 100% of cases.
The spectrum of these lesions ranges from intraductal papilloma
and papilloma with ADH or DCIS to papillary DCIS, encapsulated and solid papillary carcinoma, and invasive papillary carcinoma.