intraductal papilloma

Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to intraductal papilloma: intraductal carcinoma

in·tra·duc·tal pap·il·lo·ma

a small, often nonpalpable, benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple.
Synonym(s): duct papilloma

intraductal papilloma

a small benign epithelial tumor in a milk duct of the breast, occasionally marked by bleeding from the nipple. See also papilloma.

Intraductal papilloma

Ductal papilloma Breast disease A benign epithelial intraductal mass seen in the breast of pre- and perimenopausal ♀, arising in ductal epithelium Clinical Breast pain, nipple discharge, palpable mass. See Breast cancer.

intraductal papilloma

A papilloma in the milk ducts of the breast, composed of fibrous tissue and blood vessels. It is the most common cause of spontaneous nipple discharge. Breast biopsies, ductograms, or examination of the discharge for malignant cells are used to evaluate the lesion. Surgery is the preferred treatment.
See also: papilloma
References in periodicals archive ?
Examples of immunohistochemistry in intraductal papilloma with florid usual ductal hyperplasia (A through D), intraductal papilloma with sclerosis (E through H), and adenomyoepithelioma (I through L; the arrow indicates a mitotic figure in [J]) (hematoxylin-eosin, original magnifications x40 [A, E, and I] and x400 [B and J]; CK5, original magnifications x400 [C and K] and X200 [F]; p63, original magnifications x400 [D and L] and X200 [G]; calponin, original magnification x400 [H]).
Results of excisional biopsies showed 1 case of invasive lobular carcinoma and 1 intraductal papilloma Benign 69% Malignant 21% Benign query representative 10% Note: Table made form pie chart
Magnetic resonance imaging of intraductal papilloma of the breast.
KEYS WORDS: Nipple Discharge, Breast Intraductal Papilloma, Duct Ectasia, Microdochectomy, Ductal Carcinoma In Situ (DCIS), Lobular Carcinoma In Situ LCIS.
Features were consistent with intraductal papilloma of salivary gland
Although the differential diagnosis includes intraductal papilloma, especially when complicated by superimposed neoplastic proliferations, (136) such lesions are usually confined to one duct and its branches, rather than the multiductal distribution of papillary DCIS.
The densely cellular neoplastic cells often appear to be streaming, and thus may be mistaken for intraductal papilloma with florid ductal hyperplasia.
Histologic examination made the diagnosis of intraductal papilloma with focal atypia (Figure 3).
Wei discusses the histologic, immunohistochemical, and prognostic features of papillary lesions, including the intraductal papilloma, papilloma harboring atypical ductal hyperplasia and ductal carcinoma in situ (DCIS), intraductal papillary carcinoma (papillary DCIS), encapsulated papillary carcinoma, solid papillary carcinoma, and invasive papillary carcinoma.
Benign intraductal papilloma is a solitary lesion of the duct that typically presents when small and nonpalpable because of the occurrence of spontaneous nipple discharge.
In the assessment of atypical papillary lesions (ADH/DCIS involving benign intraductal papilloma or papillary DCIS), immunohistochemical evaluation of the expression of HMWCK is a valuable adjunct, in which benign papillary lesions exhibit strong, mosaic reactivity throughout the lesion in 88% to 100% of cases, and atypical papillary lesions are nonreactive, indicating a clonal proliferation of luminal epithelial cells in 80% to 100% of cases.
The spectrum of these lesions ranges from intraductal papilloma and papilloma with ADH or DCIS to papillary DCIS, encapsulated and solid papillary carcinoma, and invasive papillary carcinoma.