intractable epilepsy
in·trac·ta·ble ep·i·lep·sy
epilepsy not adequately controlled by medication.
Synonym(s): pharmacoresistent epilepsy
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In addition, the multiple medications that many children with intractable epilepsy take can have an impact.
Most of these patients with intractable epilepsy have seizures that are focal and can be potentially treated.
Cian, who suffers from cerebral palsy, was diagnosed with intractable epilepsy when he was two.
Stiripentol, which is believed to inhibit the activity of several P-450 cytochromes, resulted in the highest response rate ever reported for severe myoclonic epilepsy, one of the most intractable epilepsy syndromes, Dr.
To circumvent these problems, Duncan, Read, and Brodie[6] employed a strict definition of catamenial epilepsy in their prospective study examining 40 consecutive women with intractable epilepsy. Antiepileptic drug levels were randomly measured to ensure that compliance or fluctuating drug levels did not influence seizure frequency.
Of children with the most intractable epilepsy (the hardest to control), Johns Hopkins reports improved seizure control in 67 percent.
Surgical treatment has been reported in cases of medically intractable epilepsy, but it is rarely considered (11).
"Depression may be iatrogenically induced with various antiepileptic drugs used to treat the seizure disorder or after surgical treatment of intractable epilepsy," he noted.
People with intractable epilepsy make up the majority of the patient population seen in epilepsy centers.
[11.] Petersen RC, Sharbrough FW, Jack CR: Intracarotid amobarbital testing in presurgical evaluation of patients with intractable epilepsy. Pages 1051-1061 in: Treatment of Epilepsy Principles and Practice.
The incidence of this phenomenon is especially frequent in children with intractable epilepsy. This may be a result of the unpredictability of the seizure episodes.
In this clinical procedure, patients suffering from intractable epilepsy get electrodes implanted in multiple brain regions to locate the epileptic focus and surgically remove it.
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