In addition, cancer cells often develop the capacity to utilize increased AR signaling for enhanced intracrine
Download PDF Brochure@ http://www.marketsandmarkets.com/pdfdownload.asp?id=80206120 Based on signaling type, the market is segmented into paracrine, endocrine, autocrine, juxtacrine, and other signaling types (intracrine
and neuronal signaling).
It is a tightly regulated process, controlled by a number of intracrine
and endocrine feedback loops (Wang et al., 2015; Dusso et al., 2005; Maiti and Beckman, 2007; Perwad et al., 2007).
Endocrine and intracrine
sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
Instead, exogenous FGF2 functioned to reinforce the pluripotency maintenance program of intracrine
FGF2 signaling .
In addition, PTHrP has the nuclear localization sequence and also acts via intracrine
action to promote BrCa cell proliferation.
conversion of 25(OH) D to calcitriol by T cells.
Vazquez-Tello et al., "Intracrine
signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors," Canadian Journal of Physiology and Pharmacology, vol.
White et al., "The precursor form of IL-1alpha is an intracrine
proinflammatory activator of transcription," Proceedings of the National Academy of Sciences of the United States of America, vol.
Karajannis et al., "Fetal stromal-dependent paracrine and intracrine
vascular endothelial growth factor-a/vascular endothelial growth factor receptor1 signaling promotes proliferation and motility of human primary myeloma cells," Cancer Research, vol.
Vercamer et al., "Cellular senescence involves an intracrine
prostaglandin [E.sub.2] pathway in human fibroblasts," Biochimica et Biophysica Acta (BBA)--Molecular and Cell Biology of Lipids, vol.
(10) The human ocular tissues are among the target tissues equipped for intracrine
synthesis and metabolism of oestrogens and androgens.