Initially, it was demonstrated that intracerebroventricular
infusions of salsolinol inhibited the increase in plasma ACTH and cortisol levels in lactating sheep induced by isolation stress .
In situ hybridization studies have shown high NMB production in the human hypothalamus (77) and intracerebroventricular
infusion of NMB decrease in food intake in rats (78).
Smith, "Theoretical and practical applications of the intracerebroventricular
route for CSF sampling and drug administration in CNS drug discovery research: a mini review," Journal of Neuroscience Methods, vol.
Fos expression in feeding-related brain areas following intracerebroventricular
administration of orphanin FQ in rats.
It was reported that intracerebroventricular
OT administration decreased blood pressure and was effective for 8 days after the last injection , increased nociceptive thresholds for 3 weeks after the last injection of 10 days after a previous 5-day treatment , and decreased corticosterone for 10 days after the last injection of a regime administered once a day for 5 days  in rats.
Caption: Figure 2: Representative traces of arterial pressure after intracerebroventricular
(icv) administration of aminopeptidase A (APA).
Gulyaeva, "Single intracerebroventricular
administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats," Brain Research Bulletin, vol.
At 7 days after intracerebroventricular
(ICV) cannulation, the HFD (n = 14) and LFD (n = 14) mice were separated into two groups.
Schwartz, "Effect of intracerebroventricular
[alpha]-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression," Am J Physiol Regul Integr Comp Physiol, vol.
In 1992, for the first time, Lapchak and Hefti  showed that chronic intracerebroventricular
infusion of BDNF treatment attenuated weight gain in rats.
Islam, Effect of Hesperidin on Neurobehavioral, Neuroinflammation, Oxidative Stress and Lipid Alteration in Intracerebroventricular
Streptozotocin Induced Cognitive Impairment in Mice, J.
Al igual que en ratones, en ratas tambien se han confirmado los efectos ansioliticos de la OT; en el estudio de Slattery y Neumann (2010) se mostro que una cepa de ratas Wistar caracterizada por la presencia de comportamientos relacionados con la ansiedad al recibir una infusion cronica de OT intracerebroventricular
, disminuian sus comportamientos ansiosos al ser sometidas a la caja claro/oscuro.