The goal of this modality is to provide intracellular proteins, such as intracellular enzymes
and organelle-specific proteins, as safe, tolerable and efficacious therapies.
Meanwhile, in the intracellular method, microorganism takes up particles inside its cells and begins to degrade them by intracellular enzymes
In coarse- textured soils with low organic matter, enzymatic activity depends more on intracellular enzymes
. The activity of soil enzymes is also affected by different abiotic factors such as temperature, moisture, soil pH, and oxygen content.
Hence, we recognise two types of enzymes on the basis of site of action: intracellular enzymes
or endozymes (functioning in the cell), and extracellular enzymes or exoenzymes (functioning outside the cell).
It seems that at site SDE the activity of intracellular enzymes
in the shrub microenvironment was limited by high salt content (Table 2); in the arid region the amount of annual rain is not sufficient to wash excess salts out of the shallow soil, so they accumulate in the soil at the rain penetration depth of 0.2-0.4m (Dan and Yaalon 1982; Sarah 2001).
This newly established section has already made remarkable achievements as launching collaborative drug discovery programs relating to inhibitors of kinase, one of the intracellular enzymes
that is involved in various diseases, with two U.S.
The mineral is needed for normal insulin function and metabolism, since it enhances the activity of key intracellular enzymes
in improving glucose metabolism.
They are all metabotropic, having a long-term action by activating intracellular enzymes
. The [Alpha]1 receptor activates the cellular enzyme phospholipase C (PLC), which affects changes in cell metabolism, including enzyme activity, gene expression, and protein synthesis.
Once inside the bacterium, intracellular enzymes
cleave the molecular complex, releasing the drug.
With the shift of this balance towards excessive generation of free radicals, the structure of cell organelles and membrane lipids and proteins are destroyed, intracellular enzymes
are inactivated, Deoxyribonucleic acid (DNA) damage occurs, mitochondrial aerobic respiration is blocked, lytic enzymes are activated, loss of intracellular K+ is increased, vascular permeability is decreased, the extracellular connective tissue components are destroyed, and platelet aggregation and migration of phagocytes to the tissues are increased.
PS-341 inhibits proteasomes, intracellular enzymes
that break down proteins involved in cell division.