(3) Historically, research on CBF was seriously limited by the invasive nature of the available measurement techniques, such as nitrous oxide inhalation and intracarotid
Pokorny, "Altered Blood-Brain Barrier Permeability and Its Effect on the Distribution of Evans Blue and Sodium Fluorescein in the Rat Brain Applied by Intracarotid
Injection," Physiological Research, vol.
Chopp, "Treatment of stroke in rat with intracarotid
administration of marrow stromal cells," Neurology, vol.
In epileptic patients with drug refractory seizures who underwent intracarotid
amobarbital injections (wada test), it was noticed sympathetic tonus predominance in the right hemisphere and parasympathetic predominance and up-regulation of baroreceptor sensitivity in the left hemisphere .
Evidence for this begins in neuropsychological case studies, which have identified people who had recovered at least partially from aphasia following left hemisphere stroke and then redeveloped aphasia after a later right hemisphere disruption, whether due to intracarotid
amobarbital injection or a second stroke .
infusion of leukotriene C4 selectively increases blood-brain barrier permeability after focal ischemia in rats," Journal of Cerebral Blood Flow and Metabolism, vol.
infusion of hypertonic mannitol changes permeability of blood-brain barrierto methotrexate in rats," Acta Pharmacologica Sinica, vol.
Duong et al., "Intracarotid
nitroprusside does not augment cerebral blood flow in human subjects," Anesthesiology, vol.
Kong et al., "Novel microcatheter-based intracarotid
delivery approach for MCAO/R mice," Neuroscience Letters, vol.
injection of amobarbital (Wada test) has mostly been replaced by functional MRI, which offers a non-invasive way to determine lateralisation of functions such as speech and memory.
Hippocampal memory function as reflected by the intracarotid
sodium methohexital Wada test.
Individual patient prediction of seizure lateralization in temporal lobe epilepsy: A comparison between neuropsychological memory mesures and the Intracarotid