fragilis strain that was highly resistant to multiple antibiotics, including carbapenems and metronidazole, was isolated from a patient with an intra-abdominal abscess who had been hospitalized recently in India.
Eighty-nine patients with colorectal cancer were studied; 40 (45%) required reoperation for anastomotic leak and/or intra-abdominal abscess. The group of patients requiring reoperation had significantly higher morbidity, including infections and number of readmissions when compared to the group that didn't require reoperation.
Abdominal ultrasound scan showed hepatomegaly, but a normal biliary tree with no focal liver abnormality and no evidence of intra-abdominal abscess. Due to worsening of his symptoms, gentamicin was added.
However, the update said that tocilizumab has been linked with cases of peritonitis, lower GI perforation, fistulae, and intra-abdominal abscess. Hepatic failure and liver damage have not been reported, but liver function should be monitored because of increased bilirubin levels with this drug.