For example, MDM2 or CDK4 can show positivity in intimal sarcoma, pleomorphic rhabdomyosarcoma, a subset of malignant peripheral nerve sheath tumor, and myxofibrosarcoma.
Cytogenetic and molecular cytogenetic findings of intimal sarcoma.
MDM2 Positivity by IHC and FISH in Soft Tissue and Bone Tumors Tumor Type MDM2 by MDM2 by IHC FISH ALT/WD liposarcoma + + (nuclear) Dedifferentiated liposarcoma + + (diffuse, nuclear) Pleomorphic rhabdomyosarcoma - + Intimal sarcoma + + (up to 70%) Malignant peripheral nerve sheath tumor - + (subset) Myxofibrosarcoma - + (subset) Low-grade central osteosarcoma + + Conventional osteosarcoma + (10%) - Parosteal osteosarcoma + (>85%) + Undifferentiated high-grade pleomorphic + (17%) - sarcoma of bone Abbreviations: ALT/WD, atypical lipomatous tumor/well differentiated; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; MDM2, mouse double minute 2 homolog; +, positive; -, negative.
Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery.
Intimal sarcoma of the pulmonary artery presenting as pulmonary embolism.
Immunohistochemical findings were consistent with an intimal sarcoma of the pulmonary artery (figure 2).
According to World Health Organization (WHO), there are three types of sarcoma of large blood vessels: angiosarcoma, leimyosarcoma and intimal sarcoma (3).
Pulmonary artery intimal sarcoma diagnosed by percutaneous transcatheter aspiration.
Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma.
Pulmonary artery intimal sarcoma diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration.