(21) Given equal sensitivity, a group of women with a low incidence rate would tend to have lower detection and interval cancer
rates than a group with higher incidence.
(8) Women at high risk for breast cancer caused by mutations in BRCA1, BRCA2, p53, and other genes have poor outcomes with screening mammography alone--up to 50% of cancers are interval cancers
. Annual screening MRI reduces this percentage significantly, to 11% in women with pathogenic BRCA1 mutations and to 4% in women with BRCA2 mutations.
Breast density alone was not a good predictor of interval cancer
We also know that average-risk women who are screened with ultrasonography in addition to mammography are unlikely to have palpable cancer in the interval between screens, (10,11) with the rates of such interval cancers
similar to women with fatty breasts screened only with mammography.
In other words, which patients are at highest risk for interval cancer
(invasive cancer diagnosed within 12 months of a normal mammogram), as these women would be most likely to benefit from supplemental imaging that could potentially detect a tumor not identified on digital screening mammography.
These interval cancers
are indicative of fast-growing tumors.
Risk factors and tumor characteristics of interval cancers
by mammographic density.
Since interval cancers
are not identified through routine mammography screenings, Li and colleagues analysed the mode of detection for cancers driven by rare PTVs or common variants.
However, for interval cancers
, or cancers detected within two years of a normal mammogram, only BMI was linked with having a large tumor.
"These hard-to-detect polyps, which usually occur on the right side of the colon, account for the majority of interval cancers
, which are the colon cancers that occur before you're due for your next colonoscopy," Dr.
It is recommended that women 50-74 years old have annual or biennial mammography to screen for breast cancer (10, 11), but interval cancers
occur between mammograms.
"Efforts should be focused on a better understanding of how screening interacts with tumor biology with a better understanding of the types of interval cancers
and sojourn times and how these characteristics differ by age and/or menopausal status," Dr.