There is enough literature on pulmonary involvement in RA patients, but not much study has been done in early RA patients and their HRCT patterns of interstitial disease
The relationship of thoracic lymphadenopathy to pulmonary interstitial disease
in diffuse and limited systemic sclerosis: CT findings.
While interstitial markings may be seen on chest radiographs, 20% of them may be normal (6), with high resolution chest tomography (HRCT) scan being more sensitive for HSP, particularly in detecting early interstitial disease
Emond et al., "Familial interstitial disease
with I73T mutation: a mid- and long-term study," Pediatric Pulmonology, vol.
Moreover, corticosteroid therapy is the mainstay of pulmonary interstitial disease
's treatment in Sjogren's syndrome, but the use of other immunosuppressive drugs like azathioprine, cyclophosphamide, and so forth needs to be determined, especially if the chronic form of lung involvement develops .
However, two series of patients undergoing lung biopsy for diffuse interstitial disease
reported PLCH in 3%-5% of all diffuse lung disease biopsies, in comparison with sarcoidosis, which was found in 12.5% of the same patients.
In patients with pathologically proven CMV pneumonia, CXRs usually show bilateral, reticular, interstitial disease
that classically begins in the periphery of the lower lobes and spreads centrally and superiorly, as seen in 3 of our patients.
The classic presentation of PCP is bilateral perihilar interstitial disease
that becomes progressively diffuse and causing extensive cavitations and lung destruction.
The patient's past medical history included Crohn's disease diagnosed 4 years prior, recurrent pancreatitis, pancreas divisum, chronic renal failure secondary to interstitial disease
, and papillary necrosis.
The decision to pursue a VATS biopsy was made by their attending pulmonologist, based on poor respiratory function with high-resolution computerized tomography (HRCT) changes suggestive of interstitial disease
, marked worsening of the patient's condition, or any nodular radiologic patterns.
Six patients had septic emboli, and the rest had multifocal air space disease or interstitial disease
Furthermore, the presence of interstitial disease
was not strongly correlated with measured exposure levels, suggesting that susceptibility factors other than total dose are important in the causation of disease.