There are ~23 patients reported with a DiGeorge-like syndrome and a 10p interstitial deletion
including 10p13 and/or 10p14 (2-4).
For example, about 50% of cases show CRLF2 gene rearrangements, usually associated with an interstitial deletion
of the PAR1 gene family, which juxtaposes CRLF2 to the promoter of the P2RY8 gene.
Curtis, "Molecular characterization of a novel, de novo, cryptic interstitial deletion
on 19p13.3 in a child with a cutis aplasia and multiple congenital anomalies," American Journal of Medical Genetics Part A, vol.
Three other LPP-partner genes have been reported in one case of lipoma, HMGA1 (6p21) , and in 2 different hematological malignancies: KMT2A(11q23) in a secondary acute leukemia  and BCL6(3q27) through a 3q27 interstitial deletion
in a primary central nervous system lymphomas .
Cells with interstitial deletion
may show 1 fusion (red and green overlapping), 1 green, or 1 orange signal.
Four were caused by chromosomal translocations that generated more than one fusion transcript [5-8], and another case was due to an interstitial deletion
A classic example is the small 11p interstitial deletion
in Wilms tumor and aniridia, which could only be shown via fluorescence in situ hybridization or multiplex ligation-dependent probe amplification.
Several genetic abnormalities are found in the 15q11-q13 region, including: a de novo interstitial deletion
of maternal 15q11-q13 in ~75% of cases (4 Mb deletion), paternal uniparental disomy in 2%, an imprinting center mutation in 2%, and a point mutation in E3 ubiquitin protein ligase gene (UBE3A) in 5-10% .
Array comparative genomic hybridization revealed a loss of 24 consecutive oligonucleotide probes, thus showing hemizygous interstitial deletion
on chromosome Xp21.2.
Cytogenetics revealed a 46XX chromosome complement with an interstitial deletion
of the long arm of chromosome 5 [del(5)(q15q33)].
A micro-deletion at chromosome 22q11, the most frequent interstitial deletion
found in humans, has been implicated in the onset of schizophrenia.
Ectro-amelia syndrome associated with an interstitial deletion