Leydig cell tumour

(redirected from interstitial cell tumour)

Leydig cell tumour

An uncommon gonadal tumour, which is functionally active and secretes steroids, usually testosterone; benign and malignant Leydig cell tumours are separated based on histologic features.

Clinical findings
Usually affects males, with a bimodal peak at age 5–10 and between 30 and 60. Childhood presentation is classically associated with precocious puberty in males, due to testosterone secretion by the tumour. One-third of female patients with Leydig cell tumours develop progressive masculinisation, preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation, and often acne and hirsutism, voice deepening, clitoromegaly, hair recession, and increased muscle mass.

Malignant features
> 5 cm, infiltration, vascular invasion, necrosis,  pleomorphism.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Colafrancesch M et al., "Rare association of testicular pathology: interstitial cell tumour and seminoma," in Policlinico Sez Chir, vol.
Giant adrenal myelolipoma and testicular interstitial cell tumour in a man with congenital 21-hydroxylase deficiency.

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