international normalized ratio


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Related to international normalized ratio: INR

international normalized ratio (INR),

the prothrombin time ratio that would have been obtained if a standard reagent had been used in a prothrombin time determination; the prothrombin time ratio is expressed as the patient prothrombin time divided by the mean of the prothrombin time reference interval; the prothrombin time ratio is obtained for a working reagent in the laboratory through use of a parameter designated the international sensitivity index. Compare: international sensitivity index.
Farlex Partner Medical Dictionary © Farlex 2012

international normalized ratio

(ĭn′tər-năsh′ə-nəl)
n.
A standardized measure of the clotting ability of blood based on the ratio of an individual's prothrombin time to the normal mean prothrombin time, used especially to monitor the risk of bleeding in patients receiving anticoagulant therapy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

International Normalized Ratio

Hematology A method of reporting prothrombin time–PT results for Pts receiving oral anticoagulant therapy; the INR is defined by the formula, PTPatient/PTMNPTISI that uses the international sensitivity index to adjust PT results from thromboplastin of different sources and facilitates monitoring anticoagulant therapy when using more than one lab and comparing a Pt's PT results with published standards for treatment. See Anticoagulation, International sensitivity index, Prothrombin time.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

in·ter·na·tion·al nor·mal·ized ra·ti·o

(INR) (in'tĕr-nash'ŭn-ăl nōr'măl-īzd rā'shē-ō)
The prothrombin time ratio that would have been obtained if a standard reagent had been used in a prothrombin time determination; the prothrombin time ratio is expressed as the patient's prothrombin time divided by the mean of the prothrombin time reference interval; the prothrombin time ratio is obtained for a working reagent in the laboratory through use of a parameter designated the international sensitivity index.
See also: international sensitivity index
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Biological variation of International Normalized Ratio for prothrombin times, and consequences in monitoring oral anticoagulant therapy: com puter simulation of serial measurements with goal-setting for analytical quality.
Interpreting the international normalized ratio (INR) in individuals receiving argatroban and warfarin.
An example would be differential assessment of incidence of bleeding by staff who regularly monitor international normalized ratios for one study group only.
Algorithm for Adjusting Warfarin Doses According to International Normalized Ratio (INR) Levels Day INR Dose, in mg 1 5.0 2 <1.5 5.0 1.5 to 1.9 2.5 2.0 to 2.5 1.0 to 2.5 >3.0 0.0 3 <1.5 5.0 to 10.0 1.5 to 1.9 2.5 to 5.0 2.0 to 2.5 0.0 to 2.5 2.5 to 3.0 0.0 to 2.5 >3.0 0.0 4 <1.5 10.0 1.5 to 1.9 5.0 to 7.5 2.0 to 3.0 0.0 to 5.0 >3.0 0.0 5 <1.5 10.0 1.5 to 1.9 7.5 to 10.0 2.0 to 3.0 0.0 to 5.0 >3.0 0.0 6 <1.5 7.5 to 12.5 1.5 to 1.9 5.0 to 10.0 2.0 to 3.0 0.0 to 7.5 >3.0 0.0 REFERENCES
During this time, the patient's prothrombin time international normalized ratio (INR) increased 3.5 times higher than the baseline value.
NEW ORLEANS -- Monitoring chronic warfarin therapy using point-of-care international normalized ratio testing backed by computerized decision support software is far superior to traditional anticoagulation monitoring in terms of both quality of care and cost, Dr.
When used with warfarin, large increases in the international normalized ratio (INR) or prothrombin time may occur.
Children were treated initially with unfractionated heparin for 5-7 days, followed by at least 3-6 months of warfarin to maintain an international normalized ratio of 2-3, or low-molecular-weight heparin to maintain an anti-factor Xa level of 0.5-1.0 U/mL.
Results: The baseline mean values for white blood cell count (WBC), blood urea nitrogen (BUN), creatinine and international normalized ratio (INR) were higher in the severe patient group at a significant level compared to the mild patient group.

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