internal dose


Also found in: Acronyms.

in·ter·nal dose

(in-tĕr'năl dōs)
The amount of a compound that is absorbed by the body by penetrating an epithelial barrier such as the skin, eyes, respiratory tract, or gastrointestinal tract.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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Employing the calibrated [E.sub.max] model (Equation 1), we determined benchmark internal doses for a 15% deficit in spatial memory function using peak CPF concentrations in the brain as the internal dose metric (Table 3).
A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos
With regard to the child participants, it was interesting to observe that age was inversely related to internal dose as measured in urine or toenails.
Measurements of arsenic in the urine and nails of individuals exposed to low concentrations of arsenic in drinking water from private wells in a rural region of Quebec, Canada
For evaluation of their use as exposure biomarkers (internal dose), we compared these with previously measured concentrations of the elements in blood (erythrocyte fraction) and urine (Ahmed et al.
Major limitations in using element concentrations in hair as biomarkers of exposure to toxic and essential trace elements in children
Such an interpretation would greatly restrict our ability to move from surface-level exposure measures to internal dose, pharmacokinetics, and in vivo pathophysiology.
Comment on "optimal exposure biomarkers for nonpersistent chemicals in environmental epidemiology"
The PBPK model was then used to integrate the information on various physiological and metabolic distributions to predict distributions for several internal dose metrics in the population as a whole as well as some population segments.
Human health effects of dichloromethane: key findings and scientific issues
"We were measuring response to internal dose and looking for preneoplastic lesions.
BPA as a mammary carcinogen: early findings reported in rats
Applying this relationship to our internal dose study, one may conclude that the pups from the BPA250 dams were lactationally exposed to 0.8 ug total BPA/kg BW/day, below the current U.S.
Perinatally administered bisphenol A as a potential mammary gland carcinogen in rats
It is generally assumed that the undesirable effects of BPA are associated with plasma concentrations (internal dose) rather than the administered BPA dose.
High bioavailability of bisphenol A from sublingual exposure
Figure 2 illustrates the distinct effects of different sources of variability on external dose, internal dose, or biological response.
Addressing human variability in next-generation human health risk assessments of environmental chemicals
In a longitudinal cohort study of nonsmoking African-American and Dominican women in New York City (the Northern Manhattan Mothers and Newborns Study), the authors measured PAH exposure during pregnancy using personal air monitors and quantified benzo[a]pyrene DNA adducts and genomic DNA methylation in cord blood DNA among 164 participants, and they assessed PAH internal dose using prenatal urinary metabolites in a subset of the women (n = 87).
PAH exposure, methylation, and adducts in cord blood
Relationship between administered and internal dose of BPA, and age-related changes in BPA pharmacokinetics.
Similarity of bisphenol a pharmacokinetics in rhesus monkeys and mice: relevance for human exposure
Thus, although there is a clear need to test different routes of chemical exposure when assessing toxicity, it is equally important to focus on the internal dose of the chemical in order to compare animals and people.
TSCA reform under way in congress

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