internal dose


Also found in: Acronyms.

in·ter·nal dose

(in-tĕr'năl dōs)
The amount of a compound that is absorbed by the body by penetrating an epithelial barrier such as the skin, eyes, respiratory tract, or gastrointestinal tract.
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We found no increase in the hair As concentration with increasing distance from the scalp, indicating no remaining external contamination after the alkaline washing procedure prior to analysis and that the hair As indeed reflects the internal dose.
Major limitations in using element concentrations in hair as biomarkers of exposure to toxic and essential trace elements in children
This shift from apical endpoints in intact animals after exposure to a certain external dose to mechanistically based descriptions of the toxic processes makes it evident that emphasis should be put on the estimation of the internal dose in different tissues and cells.
Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods
With regard to the child participants, it was interesting to observe that age was inversely related to internal dose as measured in urine or toenails.
Measurements of arsenic in the urine and nails of individuals exposed to low concentrations of arsenic in drinking water from private wells in a rural region of Quebec, Canada
The PBPK model was then used to integrate the information on various physiological and metabolic distributions to predict distributions for several internal dose metrics in the population as a whole as well as some population segments.
Human health effects of dichloromethane: key findings and scientific issues
1) A study by Tufts University researchers in the current issue of EHP suggests that BPA may act as a malignant mammary gland carcinogen in rats at internal doses comparable to those seen in humans.
BPA as a mammary carcinogen: early findings reported in rats
2] in diameter) occurring at internal doses relevant to human exposure, suggesting that BPA may act as a complete carcinogen.
Perinatally administered bisphenol A as a potential mammary gland carcinogen in rats
2010), and in such cases genetic variability can profoundly influence enzyme function with implications for internal dose (Figure 1).
Addressing human variability in next-generation human health risk assessments of environmental chemicals
This issue may be a key determinant of cross-species extrapolation of BPA internal dose, but it has yet to be addressed in BPA pharmacokinetic models (Edginton and Ritter 2009; Teeguarden et al.
Does rapid metabolism ensure negligible risk from bisphenol A?
Monitoring methods are needed that easily measure exposure, internal dose, susceptibility, and biological outcome.
Exposure as part of a systems approach for assessing risk
They also proposed four categories of biomarkers: internal dose, biologically effective dose, early biologic response, and susceptibility.
Signs of the times: biomarkers in perspective
The linkage between environmental exposure and dose, including internal dose and dose to target tissue, is only scantily presented.
Environmental Health: From Global to Local
Behaviour of biological indicators of internal dose and some neuro-endocrine tests in aluminium workers.
Prolactin changes as a consequence of chemical exposure

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